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dc.contributor.authorCarvalho, Leonardo José de Moura-
dc.contributor.authorOliveira, S. G.-
dc.contributor.authorTheisen, M.-
dc.contributor.authorAlves, Francisco Acácio-
dc.contributor.authorAndrade, M. C. R.-
dc.contributor.authorZanini, G. M.-
dc.contributor.authorBrígido, Maria do Carmo de Oliveira-
dc.contributor.authorOeuvray, C.-
dc.contributor.authorPóvoa, Marinete Marins-
dc.contributor.authorMuniz, José Augusto Pereira Carneiro-
dc.contributor.authorDruilhe, P.-
dc.contributor.authorDaniel-Ribeiro, Cláudio Tadeu-
dc.date.accessioned2019-05-31T18:13:12Z-
dc.date.available2019-05-31T18:13:12Z-
dc.date.issued2004-
dc.identifier.citationCARVALHO, L. J. M. et al. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian Journal of Immunology, v. 59, n. 4, p. 363-372, Apr. 2004.pt_BR
dc.identifier.issn0300-9475-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/3736-
dc.description.abstractThe immunogenicity and protective efficacy of various antigen-adjuvant fomulations derived either from the merezoite-surface protein-3(MSP-3)or the glutamate-richprotein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These Proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth. Some of the S.sciureus monkeys immunized with MSP-3 212-380 - AS02 or GLURP 27-500 - alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) stain] blodd-stage infection, and thisprotection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection usig adjuvants that are aceptable for human use and this sholud trigger further studies with those new antigens.pt_BR
dc.language.isoengpt_BR
dc.publisherWileypt_BR
dc.rightsAcesso Abertopt_BR
dc.titleImmunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levelspt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimarySaimiri / imunologiapt_BR
dc.subject.decsPrimaryPlasmodium falciparum / imunologiapt_BR
dc.subject.decsPrimaryAntígenos de Protozoáriospt_BR
dc.subject.decsPrimaryAnticorpos Antiprotozoários / análisept_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Laboratory of Malaria Research. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationStatens Seruminstitut. Clinical Biochemistry. Copenhagen, Denmark.pt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Centro Nacional de Primatas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. CECAL. Department of Primatology. Rio de Janeiro, RJ, Brazil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Laboratory of Malaria Research. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Centro Nacional de Primatas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationInstitut Pasteur. Biomedical Parasitology. Paris, France.pt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Centro Nacional de Primatas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationInstitut Pasteur. Biomedical Parasitology. Paris, France.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Laboratory of Malaria Research. Rio de Janeiro, RJ, Brasil.pt_BR


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