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Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
dc.contributor.author | Carvalho, Leonardo José de Moura | - |
dc.contributor.author | Oliveira, S. G. | - |
dc.contributor.author | Theisen, M. | - |
dc.contributor.author | Alves, Francisco Acácio | - |
dc.contributor.author | Andrade, M. C. R. | - |
dc.contributor.author | Zanini, G. M. | - |
dc.contributor.author | Brígido, Maria do Carmo de Oliveira | - |
dc.contributor.author | Oeuvray, C. | - |
dc.contributor.author | Póvoa, Marinete Marins | - |
dc.contributor.author | Muniz, José Augusto Pereira Carneiro | - |
dc.contributor.author | Druilhe, P. | - |
dc.contributor.author | Daniel-Ribeiro, Claudio Tadeu | - |
dc.date.accessioned | 2019-05-31T18:13:12Z | - |
dc.date.available | 2019-05-31T18:13:12Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | CARVALHO, L. J. M. et al. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian Journal of Immunology, v. 59, n. 4, p. 363-372, Apr. 2004. | pt_BR |
dc.identifier.issn | 0300-9475 | - |
dc.identifier.uri | http://patua.iec.gov.br//handle/iec/3736 | - |
dc.description.abstract | The immunogenicity and protective efficacy of various antigen-adjuvant fomulations derived either from the merezoite-surface protein-3(MSP-3)or the glutamate-richprotein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These Proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth. Some of the S.sciureus monkeys immunized with MSP-3 212-380 - AS02 or GLURP 27-500 - alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) stain] blodd-stage infection, and thisprotection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection usig adjuvants that are aceptable for human use and this sholud trigger further studies with those new antigens. | pt_BR |
dc.language.iso | eng | pt_BR |
dc.publisher | Wiley | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.title | Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels | pt_BR |
dc.type | Artigo | pt_BR |
dc.subject.decsPrimary | Saimiri / imunologia | pt_BR |
dc.subject.decsPrimary | Plasmodium falciparum / imunologia | pt_BR |
dc.subject.decsPrimary | Antígenos de Protozoários | pt_BR |
dc.subject.decsPrimary | Anticorpos Antiprotozoários / análise | pt_BR |
dc.creator.affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Laboratory of Malaria Research. Rio de Janeiro, RJ, Brasil. | pt_BR |
dc.creator.affilliation | Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil. | pt_BR |
dc.creator.affilliation | Statens Seruminstitut. Clinical Biochemistry. Copenhagen, Denmark. | pt_BR |
dc.creator.affilliation | Ministério da Saúde. Fundação Nacional de Saúde. Centro Nacional de Primatas. Belém, PA, Brasil. | pt_BR |
dc.creator.affilliation | Fundação Oswaldo Cruz. CECAL. Department of Primatology. Rio de Janeiro, RJ, Brazil. | pt_BR |
dc.creator.affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Laboratory of Malaria Research. Rio de Janeiro, RJ, Brasil. | pt_BR |
dc.creator.affilliation | Ministério da Saúde. Fundação Nacional de Saúde. Centro Nacional de Primatas. Belém, PA, Brasil. | pt_BR |
dc.creator.affilliation | Institut Pasteur. Biomedical Parasitology. Paris, France. | pt_BR |
dc.creator.affilliation | Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil. | pt_BR |
dc.creator.affilliation | Ministério da Saúde. Fundação Nacional de Saúde. Centro Nacional de Primatas. Belém, PA, Brasil. | pt_BR |
dc.creator.affilliation | Institut Pasteur. Biomedical Parasitology. Paris, France. | pt_BR |
dc.creator.affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Laboratory of Malaria Research. Rio de Janeiro, RJ, Brasil. | pt_BR |