Severe anemia affects both splenectomized and nonsplenectomized plasmodium falciparum-infected Aotus infulatus monkeys
Carvalho, Leonardo José de Moura
Alves, Francisco Acácio
Oliveira, Salma Gomes de
Valle, Rodrigo del Rio do
Fernandes, Andréa A. Morais
Muniz, José Augusto Pereira Carneiro
Daniel-Ribeiro, Cláudio Tadeu
Severe anemia is the earliest and a frequently fatal complication of Plasmodium falciparum infection. Here we describe Aotus infulatus as a primate model suitable to study this malaria complication. Both non-splenectomized and splenectomized monkeys receiving different inocula of P. falciparum FVO strain presented large (> 50%) decreases in hematocrit values during infection. Non-splenectomized animals were able to control parasite growth (parasitemia did not exceed 4%), but they had to be treated because of severe anemia. Three of 4 splenectomized monkeys did not control parasitemia and were treated, but developed severe anemia after treatment when presenting a negative blood film. Destruction of parasitized red blood cells alone cannot account for the degree of anemia. Non-splenectomized monkeys repeatedly infected with homologous parasites became rapidly and progressively resistant to reinfection and to the development of severe anemia. The data presented here point to A. infulatus as a suitable model for studying the pathogenesis of severe malarial infection.
xmlui.dri2xhtml.METS-1.0.item-citationCARVALHO, Leonardo J. de Moura et al. Severe anemia affects both splenectomized and nonsplenectomized plasmodium falciparum-infected Aotus infulatus monkeys. Memórias do Instituto Oswaldo Cruz, v. 98, n. 5, p. 679-689, July 2003.
xmlui.dri2xhtml.METS-1.0.item-decsPrimaryMalária / complicações
Plasmodium falciparum / parasitologia