Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria
Carvalho, Leonardo J. de Moura
Oliveira, Salma Gomes de
Alves, Francisco Acácio
Brígido, Maria do Carmo de Oliveira
Muniz, José Augusto Pereira Carneiro
Daniel-Ribeiro, Cláudio Tadeu
Aotus is one of the WHO-recommended primate models for studies in malaria, and several species can be infected with Plasmodium falciparum or P. vivax. Here we describe the successful infection of the species A. infulatus from eastern Amazon with blood stages of P. falciparum. Both intact and splenectomized animals were susceptible to infection; the intact ones were able to keep parasitemias at lower levels for several days, but developed complications such as severe anemia; splenectomized monkeys developed higher parasitemias but no major complications. We conclude that A. infulatus is susceptible to P. falciparum infection and may represent an alternative model for studies in malaria.
xmlui.dri2xhtml.METS-1.0.item-citationCARVALHO, Leonardo J. de Moura et al. Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria. Memórias do Instituto Oswaldo Cruz, v. 95 n. 3, p. 363-365, May - July 2003.
xmlui.dri2xhtml.METS-1.0.item-decsPrimaryMalária Falciparum / patologia
Primatas / parasitologia
Malária Falciparum / induzido quimicamente