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dc.contributor.authorCardoso, Marcelo M-
dc.contributor.authorFranco, Edna Cristina Santos-
dc.contributor.authorSouza, Celice C. de-
dc.contributor.authorSilva, Michelle C. da-
dc.contributor.authorGouveia, Amauri-
dc.contributor.authorGomes-Leal, Walace-
dc.date.accessioned2016-01-26T11:22:39Z-
dc.date.available2016-01-26T11:22:39Z-
dc.date.issued2013-
dc.identifier.citationCARDOSO, Marcelo M. et al. Minocycline treatment and bone marrow mononuclear cell transplantation after endothelin-1 induced striatal ischemia. Inflammation, v. 36, n. 1, p. 197-205, Feb. 2013.pt_BR
dc.identifier.urihttp://patua.iec.gov.br/handle/iec/375-
dc.description.abstractWe explored whether the modulation of microglia activation with minocycline is beneficial to the therapeutic actions of bone marrow mononuclear cells (BMMCs) transplanted after experimental stroke. Male Wistar adult rats were divided in four experimental groups: ischemiccontrol saline treated (G1, N=6), ischemic minocycline treated (G2, N=5), ischemic BMMC treated (G3, N=5), and ischemic minocycline/BMMC treated (G4, N=6). There was a significant reduction in the number of ED1+ cells in G3 animals (51.31±2.41, P>0.05), but this effect was more prominentfollowing concomitant treatment with minocycline (G4=29.78±1.56). There was conspicuous neuronal preservation in the brains of G4 animals (87.97±4.27) compared with control group (G1=47.61±2.25, P>0.05). The behavioral tests showed better functional recovery in animals ofG2, G3, and G4, compared with G1 and baseline (P>0.05). The results suggest that a proper modulation of microglia activity may contribute to a more permissive ischemic environment contributing to increased neuroprotection and functional recovery following striatal ischemia.pt_BR
dc.description.sponsorshipThis work was supported by the Brazilian National Council for Scientific and Technological Development (CNPq) and Fundação de Amparo A Pesquisa do Estado do Pará (FAPESPA). W Gomes-Leal is a principal investigator in grant number 573872/2008-2 from the Ministry of Science and Technology (MCT), Ministry of Health (MS), and CNPq (Edital CT-Biotecnologia/MCT/ CNPq/MS/SCTIE/DECIT No. 17/2008) and FAPESPA (PRONEX-FAPESPA-CNPQ-Edital 012-2009).pt_BR
dc.format.mimetypeapplication/pdf-
dc.language.isoengpt_BR
dc.publisherSpringer Verlagpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMinocycline treatment and bone marrow mononuclear cell transplantation after endothelin-1 induced striatal ischemiapt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryAcidente Vascular Cerebralpt_BR
dc.subject.decsPrimaryMinociclinapt_BR
dc.subject.decsPrimaryMedula Ósseapt_BR
dc.subject.decsPrimaryRatos Wistarpt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Laboratory of Experimental Neuroprotection and Neuroregeneration. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Laboratory of Experimental Neuroprotection and Neuroregeneration. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Laboratory of Experimental Neuroprotection and Neuroregeneration. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Laboratory of Experimental Neuroprotection and Neuroregeneration. Belém, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Laboratory of Experimental Neuroprotection and Neuroregeneration. Belém, PA, Brazil.pt_BR
dc.identifier.doi10.1007/s10753-012-9535-5-


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