Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis
Pinheiro, Luane Lopes
Lima, Ana Rita de
Martins, Danielli Martinelli
Oliveira, Edivaldo Herculano Correa de
Souza, Michel Platini Caldas de
Miranda, Carla Maria Figueiredo de Carvalho
Beltrão-Braga, Patrícia Cristina Baleeiro
Russo, Fabiele Baldino
Pignatari, Graciela Conceição
Silva filho, Ednaldo da
Researchers have used dogs with neurological sequelae caused by distemper as an experimental model for multiple sclerosis, owing to the similarities of the neuropathological changes between distemper virus-induced demyelinating leukoencephalitis and multiple sclerosis in humans. However, little is known about the role of mesenchymal stem cells in treating such clinical conditions. Therefore, we investigated the use of mesenchymal stem cells in four dogs with neurological lesions caused by the distemper virus. During the first year after cellular therapy, the animals did not demonstrate significant changes in their locomotive abilities. However, the intense (Grade V) myoclonus in three animals was reduced to a moderate (Grade IV) level. At one year after the mesenchymal stem cell infusions, three animals regained functional ambulation (Grade I), and all four dogs started to move independently (Grades I and II). In two animals, the myoclonic severity had become mild (Grade III). It was concluded that the use of mesenchymal stem cells could improve the quality of life of dogs with neurological sequelae caused by canine distemper, thus presenting hope for similar positive results in human patients with multiple sclerosis.
xmlui.dri2xhtml.METS-1.0.item-citationPINHEIRO, Luane Lopes et al. Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis. Heliyon, v. xx, n. xx, p. xx, 2019.
Esclerose Múltipla / patologia
Células-Tronco Mesenquimais / citologia
Sistema Nervoso Central