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Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus)

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2019
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Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus).pdf (4.654xmlui.dri2xhtml.METS-1.0.size-megabytes)
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http://patua.iec.gov.br//handle/iec/3821
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Matos, Gabriel Costa
Ferreira, Milene Silveira
Martins Filho, Arnaldo Jorge
Amador Neto, Orlando Pereira
Campos, Valter Miranda
Lima, Maria de Lourdes Gomes de
Rodrigues, Jéssica Cecília Pinheiro
Ribeiro, Ana Claudia da Silva
Freitas, Maria de Nazaré Oliveira
Silva, Franko de Arruda e
Chiang, Jannifer Oliveira
Casseb, Livia Medeiros Neves
Sousa, Jorge Rodrigues de
Quaresma, Juarez Antônio Simões
Martins, Lívia Carício
Vasconcelos, Pedro Fernando da Costa
Carvalho, Valéria Lima
xmlui.dri2xhtml.METS-1.0.item-abstract
The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman primates, wild rodents and mosquitoes as well as mice used as sentinels. The virus is able to cause febrile disease in humans. Here we describe for the first time pathologic and biochemical findings in golden hamsters (Mesocricetus auratus) infected with the prototype GMAV. Blood and organs of infected and control animals were collected every 24 h after infection from the 1st to the 7th day post infection (dpi) and at 21 dpi when experiment was ended. The tissues were processed for histopathology and immunohistochemistry. The blood and serum were used to determine viremia and biochemical markers plus to detect anti-GMAV antibodies. The viremia was early detected already on the 1st dpi and it was no longer detected on the 3rd dpi. Total antiGMAV antibodies were detected from the 6th dpi. Hepatic markers as ALT of infected animals were increased and showed statistically significant difference in comparison with control animals, indicating damage of the liver; indeed the liver was the most affected organ, but other organs presented lesions and positive GMAV immunostaining as brain, lung, liver, spleen, and kidney. Our findings indicate that golden hamsters are a good animal model for experimental infection of the GMAV.
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MATOS, Gabriel Costa et al. Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus). Microbial Pathogenesis, v. 135, n.103627, 2019.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Orthobunyavirus / patogenicidade
Arbovirus / isolamento & purificação
Mesocricetus / anatomia & histologia
Infecções por Arbovirus
Infecções por Bunyaviridae
Vírus Guama
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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br