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dc.contributor.authorMatos, Gabriel Costa-
dc.contributor.authorFerreira, Milene Silveira-
dc.contributor.authorMartins Filho, Arnaldo Jorge-
dc.contributor.authorAmador Neto, Orlando Pereira-
dc.contributor.authorCampos, Valter Miranda-
dc.contributor.authorLima, Maria de Lourdes Gomes de-
dc.contributor.authorRodrigues, Jéssica Cecília Pinheiro-
dc.contributor.authorRibeiro, Ana Claudia da Silva-
dc.contributor.authorFreitas, Maria de Nazaré Oliveira-
dc.contributor.authorSilva, Franko de Arruda e-
dc.contributor.authorChiang, Jannifer Oliveira-
dc.contributor.authorCasseb, Livia Medeiros Neves-
dc.contributor.authorSousa, Jorge Rodrigues de-
dc.contributor.authorQuaresma, Juarez Antônio Simões-
dc.contributor.authorMartins, Lívia Carício-
dc.contributor.authorVasconcelos, Pedro Fernando da Costa-
dc.contributor.authorCarvalho, Valéria Lima-
dc.date.accessioned2019-08-09T13:49:01Z-
dc.date.available2019-08-09T13:49:01Z-
dc.date.issued2019-
dc.identifier.citationMATOS, Gabriel Costa et al. Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus). Microbial Pathogenesis, v. 135, n.103627, 2019.pt_BR
dc.identifier.issn1096-1208-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/3821-
dc.description.abstractThe Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman primates, wild rodents and mosquitoes as well as mice used as sentinels. The virus is able to cause febrile disease in humans. Here we describe for the first time pathologic and biochemical findings in golden hamsters (Mesocricetus auratus) infected with the prototype GMAV. Blood and organs of infected and control animals were collected every 24 h after infection from the 1st to the 7th day post infection (dpi) and at 21 dpi when experiment was ended. The tissues were processed for histopathology and immunohistochemistry. The blood and serum were used to determine viremia and biochemical markers plus to detect anti-GMAV antibodies. The viremia was early detected already on the 1st dpi and it was no longer detected on the 3rd dpi. Total antiGMAV antibodies were detected from the 6th dpi. Hepatic markers as ALT of infected animals were increased and showed statistically significant difference in comparison with control animals, indicating damage of the liver; indeed the liver was the most affected organ, but other organs presented lesions and positive GMAV immunostaining as brain, lung, liver, spleen, and kidney. Our findings indicate that golden hamsters are a good animal model for experimental infection of the GMAV.pt_BR
dc.description.sponsorshipThis study was supported by the Evandro Chagas Institute (Ministry of Health of Brazil) and by scholarship from National Council for Scientific and Technological Development (CNPq). PFCV was supported by CNPq grant 303999/2016-0.pt_BR
dc.language.isoengpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleExperimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus)pt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryOrthobunyavirus / patogenicidadept_BR
dc.subject.decsPrimaryArbovirus / isolamento & purificaçãopt_BR
dc.subject.decsPrimaryMesocricetus / anatomia & histologiapt_BR
dc.subject.decsPrimaryInfecções por Arboviruspt_BR
dc.subject.decsPrimaryInfecções por Bunyaviridaept_BR
dc.subject.decsPrimaryVírus Guamapt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade Federal do Pará. Instituto de Ciências Biológicas. Belém, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.identifier.doi10.1016/j.micpath.2019.103627-


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