• Regulation of the immune checkpoint indoleamine 2,3-dioxygenase expression by Epstein–Barr Virus 

  Sawada, Leila; Vallinoto, Antônio Carlos Rosário; Costa, Igor Brasil (MDPI, 2021)

  Epstein–Barr virus (EBV) is an oncovirus ubiquitously distributed and associated with different types of cancer. The reason why only a group of infected people develop cancer is still unknown. EBV-associated cancers represent ...

• TNFA-308G>A and IL10-1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection 

  Santiago, Angélica Menezes; Amoras, Ednelza da Silva Graça; Queiroz, Maria Alice Freitas; Conde, Simone Regina Souza da Silva; Cayres-Vallinoto, Izaura Maria Vieira; Ishak, Ricardo; Vallinoto, Antonio Carlos Rosário (BMC, 2021)

  Background: Genetic changes may induce dysregulated cytokine production and afect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-infammatory cytokines determines ...

• Detection of a novel species A, DS-1-like, G4P[6] rotavirus strain from a Brazilian child with gastroenteritis 

  Bandeira, Renato da Silva; Souto, Lizandra Caroline dos Santos; Souza, Layse Costa de; Linhares, Alexandre da Costa; Mascarenhas, Joana D’Arc Pereira (Wiley, 2021)

  Rotaviruses belonging to species A (RVA) remain among the most common causes of severe gastroenteritis in children aged <5 years, leading to substantial morbidity and mortality worldwide. Genome reassortment events between ...

• Molecular analysis of G3P[6] rotavirus in the Amazon region of Brazil: evidence of reassortment with equine-like strains 

  Serra, Ana C. Silva; Sousa Júnior, Edivaldo costa; Cruz, Jonas F; Lobo, Patrícia dos Santos; Penha Júnior, Edvaldo Tavares da; Bandeira, Renato S; Bezerra, Delana Andreza Melo; Mascarenhas, Joana D’Arc Pereira; Guerra, Sylvia de Fátima dos Santos; Soares, Luana da Silva (Future Science Group, 2021)

  Aim: To perform a molecular analysis of rotavirus A (RVA) G3P[6] strains detected in 2012 and 2017 in the Amazon region of Brazil. Materials & methods: Eighteen RVA G3P[6] strains were collected from children aged under ...

• Serological markers for hepatitis a among captive and free-living wild mammals in the State of Para, Brazil 

  Bernal, Marcella Katheryne Marques; Souza, Alex Júnior Souza de; Nunes, Heloisa Marceliano; Malheiros, Andreza Pinheiro; Chagas, André Antônio Corrêa das; Andrade, Sara Letícia dos Santos; Figueiredo, Andréa Lima Silva; Cecim, Amanda Desirée Assunção; Pereira, Washington Luiz Assunção (Universidade do Estado de Londrina, 2021)

  The hepatitis A virus (HAV, Hepatovirus A) in humans has a relevant impact on public health, especially in geographic regions with poor basic sanitation, such as the Brazilian Amazon. Isolates related to hepatoviruses have ...

• Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection 

  Brito, Caio Vinicius Botelho; Rodrigues, Érika Dayane Leal; Martins, Fernanda Monik Silva; Tavares, Lavínia Dias; Lima, André Luis de Sousa Nogueira; Ferreira, Lucas Carvalho; Santana, Carlos Junior Lopes; Brito, João Augusto Gomes de Souza Monteiro de; Casseb, Lívia Medeiros Neves; Diniz Junior, José Antônio Picanço (Instituto de Medicina Tropical, 2021)

  Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution ...

• The crab heparin-like compound exhibits a strong inhibitory effect on infections by dengue virus-2 

  Almeida, Marlyanne M. C. S. de; A. Júnior, Renato F. de; Aquino, Ana A. de; Pinto, Lívia de Lourdes; Machado, Paula R. L; Chavante, Suely F; Farias, Kleber Juvenal Silva; Andrade, Giulianna P. V. de (Bentham Science Publishers, 2021)

  Background: According to the World Health Organization (WHO), two-fifths of the world population is at risk of infection by DENV. There are no safe and effective vaccines estab-lished. Sulfated glycosaminoglycans such as ...

• Serological evidence of Eastern equine encephalitis circulation in equids in Pará state, Brazil 

  Nunes, Josynélia do Socorro da Silva Sena; Casseb, Lívia Medeiros Neves; Guimarães, Ricardo José de Paula Souza e; Reis, Wilgner Duarte Magalhães; Barros, Bruno de Cássio Veloso de; Ferreira, Milene Silveira; Chiang, Jannifer Oliveira; Pinheiro, Helder Henrique Costa; Vasconcelos, Pedro Fernando da Costa; Cruz, Ana Cecília Ribeiro (Sociedade de Medicina Veterinária do Rio de Janeiro, 2021)

  Serum samples from 89 equids were analyzed (75 horses, 9 donkeys, and 5 mules) from the municipality of Viseu, Pará state, Brazil. Samples were collected in November 2014 and August 2015. The antibody prevalence against ...

• Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys 

  Alcantara, Bianca Nascimento de; Imbeloni, Aline Amaral; Durans, Darlene de Brito Simith; Araújo, Marialva Tereza Ferreira de; Cruz, Ermelinda do Rosário Moutinho da; Carvalho, Carlos Alberto Marques de; Mendonça, Maria Helena Rodrigues de; Sousa, Jorge Rodrigues de; Moraes, Adriana Freitas; Martins Filho, Arnaldo Jorge; Lima, Maria de Lourdes Gomes; Amador Neto, Orlando Pereira; Chiang, Jannifer Oliveira; Scalercio, Sarah Raphaella Rocha de Azevedo; Carneiro, Liliane Almeida; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa; Medeiros, Daniele Barbosa de Almeida (Nature Research, 2021)

  The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a ...

• Clinical, epidemiological and climatic factors related to the occurrence of cutaneous leishmaniasis in an endemic area in northeastern Brazil 

  Oliveira, R. S; Pimentel, K. B. A; Moura, M. L; Aragão, C. F; Guimarães e Silva, A. S; Bezerra, J. M. T; Melo, M. N; Pinheiro, V. C. S (Instituto Internacional de Ecologia, 2021)

  Cutaneous leishmaniasis (CL) is a neglected tropical disease with a wide distribution in the Americas. Brazil is an endemic country and present cases in all states. This study aimed to describe the occurrence, the underlying ...

• Prenatal disorders and congenital Zika syndrome in squirrel monkeys 

  Imbeloni, Aline Amaral; Alcantara, Bianca Nascimento de; Coutinho, Leandro Nassar; Scalercio, Sarah Raphaella Rocha de Azevedo; Carneiro, Liliane Almeida; Oliveira, Karol Guimarães; Martins Filho, Arnaldo Jorge; Durans, Darlene de Brito Simith; Silva, Wellington Bandeira da; Nunes, Bruno Tardelli Diniz; Casseb, Livia Medeiros Neves; Chiang, Jannifer Oliveira; Carvalho, Carlos Alberto Marques de; Machado, Mariana Borges; Quaresma, Juarez Antônio Simões; Medeiros, Daniele Barbosa de Almeida; Vasconcelos, Pedro Fernando da Costa (Nature Research, 2021)

  During the Zika virus (ZIKV) outbreak in Brazil (2015–2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this ...

• Incidence of viral hepatitis in brazil from 2009 to 2018: an epidemiological study of confirmed cases of viral hepatitis 

  Silva, Alessandra Pereira da; Silva, Andressa Pereira; Souza, Lohana Marques Leal de; Peixoto, Natália de Oliveira; Gonçalves, Evonnildo Costa; Vianez Júnior, João Lídio da Silva Gonçalves (Sociedade Brasileira de Medicina Tropical, 2021)

  INTRODUCTION: Viral hepatitis is a major public health problem. It is necessary to understand the epidemic, verifying the combination of biological and demographic characteristics. METHODS: This is an analytical ecological ...

• The TGFB1-509C/T polymorphism and elevated TGF-beta 1 levels are associated with chronic hepatitis C and cirrhosis 

  Brito, William Botelho de; Queiroz, Maria Alice Freitas; Amoras, Ednelza da Silva Graça; Lima, Sandra Souza; Conde, Simone Regina Souza da Silva; Santos, Eduardo José Melo dos; Cayres-Vallinoto, Izaura Maria Vieira; Ishak, Ricardo; Vallinoto, Antonio Carlos Rosário (Elsevier, 2020)

  The IFN-γ and TGF-β1 cytokines perform antagonistic activities in the immune response, and polymorphisms in these genes may induce changes in their plasma levels and influence the course of chronic Hepacivirus C (HCV) ...

• Near-complete genome of cosavirus A from a child hospitalized with acute gastroenteritis, Brazil 

  Lobo, Patrícia dos Santos; Cardoso, Jedson Ferreira; Barata, Rafael Ribeiro; Lemos, Poliana da Silva; Guerra, Sylvia de Fátima dos Santos; Soares, Luana da Silva; Nunes, Marcio Roberto Teixeira; Mascarenhas, Joana D’Arc Pereira (Elsevier, 2020)

  Acute gastroenteritis (AG) is responsible for 525,000 deaths worldwide in children under-5-years and is caused by the Human Cosavirus (HCoSV; family Picornaviridae, Genus Cosavirus). Although its health importance, a ...

• Chikungunya virus detection in Aedes aegypti and Culex quinquefasciatus during an outbreak in the Amazon Region 

  Cruz, Ana Cecília Ribeiro; Nunes Neto, Joaquim Pinto; Silva, Sandro Patroca da; Silva, Eliana Vieira Pinto da; Pereira, Glennda Juscely Galvão; Santos, Maissa Maia; Monteiro, Hamilton Antônio de Oliveira; Santos, Flavia Barreto dos; Guimarães, Ricardo José de Paula Souza e; Aragão, Carine Fortes; Martins, Lívia Carício (MDPI, 2020)

  Chikungunya virus (CHIKV) was first reported in Brazil in 2014 and, after it spread countrywide, an outbreak of febrile illness with reports of arthralgia happened in the municipality of Xinguara, Pará, Brazil in 2017, ...

• Sequential serological surveys in the early stages of the coronavirus disease epidemic: limitations and perspectives 

  Vieira, Marcelo Adriano da Cunha e Silva; Vieira, Chrystiany Plácido de Brito; Borba, Amaríles de Souza; Melo, Maria Clara de Carvalho; Oliveira, Marilene de Sousa; Melo, Rodrigo Moraes; Nunes, Vanessa Veloso; Santana, Wesllany Sousa; Aguiar, Yara Amorim de (Sociedade Brasileira de Medicina Tropical, 2020)

  Introduction: Estimates of the number of individuals infected by severe acute respiratory syndrome coronavirus 2 are important for health planning and establishment of expectations regarding herd immunity. Methods: Seven ...

• Genotypes of Epstein–Barr virus (EBV1/EBV2) in individuals with infectious mononucleosis in the metropolitan area of Belém, Brazil, between 2005 and 2016 

  Monteiro, Talita Antônia Furtado; Costa, Iran Barros; Costa, Igor; Corrêa, Thais Letícia dos Santos; Coelho, Beatriz Monteiro Rodrigues; Silva, Amanda Emanuelle Santos; Ramos, Francisco Lúzio de Paula; Martins Filho, Arnaldo Jorge; Monteiro, José Luiz Furtado; Siqueira, Jones Anderson Monteiro; Gabbay, Yvone Benchimol; Sousa, Rita Catarina Medeiros (Brazilian Society of Infectious Diseases, 2020)

  Two types of Epstein Barr virus (EBV1/EBV2) have been shown to infect humans. Although their genomes are similar, the regions containing the EBNA genes differ. This study aimed to characterize the EBV genotypes of infectious ...

• Zika structural genes determine the virulence of African and Asian lineages 

  Nunes, Bruno Tardelli Diniz; Fontes-Garfias, Camila R; Shan, Chao; Muruato, Antonio E; Nunes, Jannyce G. C; Burbano, Rommel M. R; Vasconcelos, Pedro Fernando da Costa; Shi, Pei-Yong; Medeiros, Daniele Barbosa de Almeida (Taylor & Francis, 2020)

  The Asian lineage of Zika virus (ZIKV) is responsible for the recent epidemics in the Americas and severe disease, whereas the African lineage of ZIKV has not been reported to cause epidemics or severe disease. We constructed ...

• Characterization of rotavirus possessing a DS-1-like VP3 gene from pigs in Brazil: evidence for zooanthroponotic transmission 

  Neves, Mayara A. O; Sousa Júnior, Alcinês da Silva; Camargo, Daniel S. de; Lobo, Patrícia S; Bandeira, Renato S; Soares, Luana da Silva; Mascarenhas, Joana D'Arc Pereira (Elsevier, 2020)

  Porcine group A rotavirus (RVA) strains SUI15A and SUI24A are suggested to have VP3 genes of human origin possessing DS-1-like backbone. The aim of the present study was to analyse the genome of two strains (SUI15A and ...

• Nearly complete genome sequences of enterovirus 96 and enterovirus 99 strains isolated in the northern region of Brazil 

  Machado, R. Scerni; Ferreira, J. Lima; Alves, J. C. Santos; Bandeira, R. Silva; Lemos, P. Silva; Franco Filho, L. Chaves; Cardoso, Jedson Ferreira; Vianez Júnior, João Lídio da Silva Gonçalves; Tavares Neto, Fernando (American Society for Microbiology, 2019)

  In this study, we report the nearly complete genome sequences of one enterovirus 96 (EV-C96) isolate (strain 3499/BRA-PA/2010) and two enterovirus 99 (EV-C99) isolates (strains 3291/BRA-PA/2010 and 3944/BRA-PA/2011). The ...

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