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dc.contributor.authorQuaresma, Juarez Antônio Simões-
dc.date.accessioned2019-09-25T12:40:31Z-
dc.date.available2019-09-25T12:40:31Z-
dc.date.issued2019-
dc.identifier.citationQUARESMA, Juarez Antônio Simões. Organization of the skin immune system and compartmentalized immune responses in infectious diseases. Clinical Microbiology Reviews, v. 32, n. 4 p. 1-35, July 2019.pt_BR
dc.identifier.issn1098-6618-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/3931-
dc.description.abstractThe skin is an organ harboring several types of immune cells that participate in innate and adaptive immune responses. The immune system of the skin comprises both skin cells and professional immune cells that together constitute what is designated skin-associated lymphoid tissue (SALT). In this review, I extensively discuss the organization of SALT and the mechanisms involved in its responses to infectious diseases of the skin and mucosa. The nature of these SALT responses, and the cellular mediators involved, often determines the clinical course of such infections. I list and describe the components of innate immunity, such as the roles of the keratinocyte barrier and of inflammatory and natural killer cells. I also examine the mechanisms involved in adaptive immune responses, with emphasis on new cytokine profiles, and the role of cell death phenomena in host-pathogen interactions and control of the immune responses to infectious agents. Finally, I highlight the importance of studying SALT in order to better understand host-pathogen relationships involving the skin and detail future directions in the immunological investigation of this organ, especially in light of recent findings regarding the skin immune systempt_BR
dc.description.sponsorshipCNPq/Brazil (grant numbers 302553/2015-0 and 116427/2016-7)pt_BR
dc.language.isoengpt_BR
dc.publisherAmerican Society for Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.titleOrganization of the skin immune system and compartmentalized immune responses in infectious diseasespt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryPele / imunologiapt_BR
dc.subject.decsPrimarySistema Imunitáriopt_BR
dc.subject.decsPrimaryTecido Linfoidept_BR
dc.subject.decsPrimaryCitocinaspt_BR
dc.subject.decsPrimaryImunidade Inatapt_BR
dc.subject.decsPrimaryQueratinócitospt_BR
dc.subject.decsPrimaryLinfócitospt_BR
dc.creator.affilliationState University of Pará. Center of Biological and Health Sciences. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Federal University of Pará. Tropical Medicine Center. Belém, PA, Brazil / São Paulo University. School of Medicine. São Paulo, SP, Brazil.pt_BR
dc.identifier.doi10.1128/CMR.00034-18-


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