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Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases

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2019
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Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases.pdf (2.418xmlui.dri2xhtml.METS-1.0.size-megabytes)
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http://patua.iec.gov.br//handle/iec/3934
xmlui.dri2xhtml.METS-1.0.item-author
Sousa, Jorge Rodrigues de
Vasconcelos, Pedro Fernando da Costa
Quaresma, Juarez Antônio Simões
xmlui.dri2xhtml.METS-1.0.item-abstract
Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of macrophage phenotypic heterogeneity has been investigated since the 1980s, and more recent studies have identified a diverse spectrum of phenotypic subpopulations. Several types of macrophages play a central role in the response to infectious agents and, along with other components of the immune system, determine the clinical outcome of major infectious diseases. Here, we review the functions of various macrophage phenotypic subpopulations, the concept of macrophage polarization, and the influence of these cells on the evolution of infections. In addition, we emphasize their role in the immune response in vivo and in situ, as well as the molecular effectors and signaling mechanisms used by these cells. Furthermore, we highlight the mechanisms of immune evasion triggered by infectious agents to counter the actions of macrophages and their consequences. Our aim here is to provide an overview of the role of macrophages in the pathogenesis of critical transmissible diseases and discuss how elucidation of this relationship could enhance our understanding of the host–pathogen association in organ-specific immune responses
xmlui.dri2xhtml.METS-1.0.item-citation
SOUSA, Jorge Rodrigues de; VASCONCELOS, Pedro Fernando da Costa; QUARESMA, Juarez Antônio Simões. Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases. Infection and Drug Resistance, v. 12, p. 2589-2611. 2019
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Macrófagos / citologia
Ativação de Macrófagos
Fenótipo
Doenças Transmissíveis / imunologia
xmlui.dri2xhtml.METS-1.0.item-rights
Acesso Aberto
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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br