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Molecular identification, genotyping, phenotyping, and antifungal susceptibilities of medically important trichosporon, apiotrichum, and cutaneotrichosporon species

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2019
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Molecular identification, genotyping, phenotyping, and antifungal susceptibilities of medically important trichosporon, apiotrichum, and cutaneotrichosporon species.pdf (556.7xmlui.dri2xhtml.METS-1.0.size-kilobytes)
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http://patua.iec.gov.br//handle/iec/3995
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Espirito Santo, Elaine Patrícia Tavares do
Monteiro, Ruan Campos
Costa, Ana Roberta Fusco da
Silva, Silvia Helena Marques da
xmlui.dri2xhtml.METS-1.0.item-abstract
Recently, Trichosporon taxonomy has been reevaluated and new genera of the Trichosporonaceae family have been described. Here, 26 clinical isolates were submitted for identification via sequencing of the intergenic space 1 (IGS1) region, genotyping, and investigation of virulence factors. Antifungal susceptibility was determined using the CLSI broth microdilution method for fluconazole (FLC), itraconazole (ITC), and amphotericin B (AMB). Of these, 24 isolates were identified, including 12 T. asahii, 4 T. inkin, 3 T. faecale, 1 T. coremiiforme, 1 T. japonicum, 2 Cutaneotrichosporon dermatis (formerly T. dermatis), and 1 Apiotrichum mycotoxinivorans (formerly T. mycotoxinivorans). Species-level identification of 2 isolates was not successful; they were described as Trichosporon sp. We observed optimal colonial development at 35-40 °C. Lipase was the major extracellular enzyme produced (100%); caseinase was not produced (0%). Biofilms were produced by all isolates (classified as low). High AMB minimum inhibitory concentration (MIC) was observed, with all strains resistant. Fluconazole was the most active drug among the antifungals tested. However, high MICs for FLC were observed in C. dermatis and A. mycotoxinivorans species, which also showed resistance to ITC and AMB. This study, conducted in the Northern region of Brazil, identified 5 Trichosporon species along with C. dermatis and A. mycotoxinivorans and demonstrated their pathogenic potential through their ability to produce important virulence factors. This may contribute to our understanding of the epidemiology and factors related to the pathogeneses of species in the Trichosporonaceae family.
xmlui.dri2xhtml.METS-1.0.item-citation
ESPIRITO SANTO, Elaine Patrícia Tavares do et al. Molecular identification, genotyping, phenotyping, and antifungal susceptibilities of medically important trichosporon, apiotrichum, and cutaneotrichosporon species. Mycopathologia, v. 185, n. 2, p.307-317, Apr. 2020.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Trichosporon / classificação
Trichosporon / isolamento & purificação
Fungos Mitospóricos
Antifúngicos
Fatores de Virulência
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  • SABMI - Artigos Científicos

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
Suporte ao site - Wesin Alves