• Portal do Governo Brasileiro
  • Atualize sua Barra de Governo
Logo
    • English
    • español
    • português (Brasil)
    • English
    • español
    • português (Brasil)
  • xmlui.dri2xhtml.structural.login
xmlui.ArtifactBrowser.ItemViewer.trail 
  •   xmlui.general.dspace_home
  • CENTRO NACIONAL DE PRIMATAS
  • CENP - Artigos Científicos
  • xmlui.ArtifactBrowser.ItemViewer.trail
  •   xmlui.general.dspace_home
  • CENTRO NACIONAL DE PRIMATAS
  • CENP - Artigos Científicos
  • xmlui.ArtifactBrowser.ItemViewer.trail
JavaScript is disabled for your browser. Some features of this site may not work without it.

Antiviral activity of chloroquine against Dengue virus type 2 replication in Aotus Monkeys

Thumbnail
xmlui.dri2xhtml.METS-1.0.item-date
2015
xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
Antiviral activity of chloroquine against Dengue virus type 2 replication in Aotus Monkeys.pdf (351.5xmlui.dri2xhtml.METS-1.0.size-kilobytes)
xmlui.mirage2.itemSummaryView.MetaData
xmlui.ArtifactBrowser.ItemViewer.show_full
xmlui.dri2xhtml.METS-1.0.item-uri
http://patua.iec.gov.br//handle/iec/4015
xmlui.dri2xhtml.METS-1.0.item-author
Farias, Kleber Juvenal Silva
Machado, Paula Renata Lima
Muniz, José Augusto Pereira Carneiro
Imbeloni, Aline Amaral
Fonseca, Benedito Antônio Lopes da
xmlui.dri2xhtml.METS-1.0.item-abstract
Dengue virus (DENV) of the Flaviviridae family is a single positive-stranded RNA virus that is transmitted by Aedes aegypti and Aedes albopictus mosquitoes. The objective of this study was to investigate the use of chloroquine (CLQ) as an antiviral drug against dengue virus in monkeys. To analyze the action of the drug in vivo, nonhuman primates groups (Aotus azarai infulatus) were inoculated with a subcutaneous injection of a virulent strain of DENV-2, treated and untreated CLQ. Blood hematological, viremia, and serum biochemical values were obtained from 16 DENV-2-inoculated, treated and untreated; four received only CLQ and one mock-infected Aotus monkeys. Monkey serum samples (day 0–10 post-inoculation) were assayed by reverse transcription polymerase chain reaction and Cytometric Bead Array for determination of viremia and inflammatory cytokines, respectively. Additionally, body temperature and activity levels were determined. In the present work, CLQ was effective on replication of DENV-2 in Aotus monkeys; a time viremia reduction was observed compared with the controls. The concentration of tumor necrosis factor alpha and interferon gamma in the serum of the animals had a statistically significant reduction in the groups treated with CLQ after infection compared with the controls. A significant decrease in systemic levels of the liver enzyme aspartate aminotransferase (AST) was also observed in the animals treated with CLQ after infection compared with the controls. These results suggest that CLQ interferes in DENV-2 replication in Aotus monkeys.
xmlui.dri2xhtml.METS-1.0.item-citation
FARIAS, Kleber Juvenal Silva et al. Antiviral activity of chloroquine against Dengue virus type 2 replication in Aotus Monkeys. Viral Immunology, v. 28, n. 3, p. 161-169, Apr. 2015.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Primatas / anatomia & histologia
Aotus trivirgatus / anatomia & histologia
Vírus da Dengue / patogenicidade
Dengue / virologia
Cloroquina / administração & dosagem
Antivirais / administração & dosagem
Viremia / veterinária
Citocinas / sangue
Reação em Cadeia da Polimerase / métodos
xmlui.dri2xhtml.METS-1.0.item-rights
Acesso Aberto
xmlui.mirage2.itemSummaryView.Collections
  • CENP - Artigos Científicos

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

xmlui.ArtifactBrowser.Navigation.head_browse

xmlui.ArtifactBrowser.Navigation.head_all_of_dspacexmlui.ArtifactBrowser.Navigation.communities_and_collectionsxmlui.ArtifactBrowser.Navigation.browse_dateissuedxmlui.ArtifactBrowser.Navigation.browse_authorxmlui.ArtifactBrowser.Navigation.browse_titlexmlui.ArtifactBrowser.Navigation.browse_subjectxmlui.ArtifactBrowser.Navigation.head_this_collectionxmlui.ArtifactBrowser.Navigation.browse_dateissuedxmlui.ArtifactBrowser.Navigation.browse_authorxmlui.ArtifactBrowser.Navigation.browse_titlexmlui.ArtifactBrowser.Navigation.browse_subject

xmlui.EPerson.Navigation.my_account

xmlui.EPerson.Navigation.loginxmlui.EPerson.Navigation.register

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br