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Phylogenomic perspective on a unique mycobacterium bovis clade dominating bovine tuberculosis infections among cattle and buffalos in Northern Brazil

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2020
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Phylogenomic perspective on a unique mycobacterium bovis clade dominating bovine tuberculosis infections among cattle and buffalos in Northern Brazil.pdf (3.470xmlui.dri2xhtml.METS-1.0.size-megabytes)
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http://patua.iec.gov.br//handle/iec/4072
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Conceição, Marília Lima da
Conceição, Emilyn Costa
Furlaneto, Ismari Perini
Silva, Sandro Patroca da
Guimarães, Arthur Emil dos Santos
Gomes, Pedro
Boschiroli, María Laura
Michelet, Lorraine
Kohl, Thomas Andreas
Kranzer, Katharina
Francez, Loreno da Costa
Lima, Luana Nepomuceno Gondim Costa
Portugal, Isabel
Perdigão, João
Lima, Karla valéria Batista
xmlui.dri2xhtml.METS-1.0.item-abstract
Lack of routine surveillance in countries endemic for bovine tuberculosis (TB) and limited laboratory support contributes to the inability to differentiate the Mycobacterium tuberculosis Complex species, leading to an underestimated burden of the disease. Here, Whole-Genome Sequencing of Mycobacterium bovis isolated from tissues with TB-like lesions obtained from cattle and buffalos at Marajó Island, Brazil, demonstrates that recent transmission of M. bovis is ongoing at distinct sites. Moreover, the M. bovis epidemiology in this setting is herein found to be dominated by an endemic and unique clade composed of strains evolved from a common ancestor that are now genetically differentiated from other M. bovis clades. Additionally, envisioning a rapid strain differentiation and tracing across multiple settings, 28 globally validated strain-specific SNPs were identified, three of which considered as robust markers for the M. bovis Marajó strain. In conclusion, this study contributes with data regarding the identification of a novel M. bovis phylogenetic clade responsible for ongoing transmission events in both cattle and buffalo species in Brazil, provides a framework to investigate the dissemination of this highly prevalent strain and, holds the potential to inform TB control strategies that may help to prevent the spread of bovine and zoonotic TB.
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CONCEIÇÃO, Marília Lima da et al. Phylogenomic perspective on a unique mycobacterium bovis clade dominating bovine tuberculosis infections among cattle and buffalos in Northern Brazil. Scientific Reports, v. 10, n. 1747, p. 1-13, 2020.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Tuberculose Bovina / diagnóstico
Tuberculose Bovina / transmissão
Mycobacterium bovis / isolamento & purificação
Mycobacterium bovis / virologia
Sequenciamento Completo do Genoma / métodos
Genoma Bacteriano / genético
Gado
Ilha de Marajó (PA)
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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br