Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Belém, Pará, North Region of Brazil

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2020xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
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http://patua.iec.gov.br//handle/iec/4091xmlui.dri2xhtml.METS-1.0.item-author
Lima, Ana Beatriz Figueiredo de
Sá, Keyla Santos Guedes de
Torres, Maria Karoliny da Silva
Soares, Luana da Silva
Resques, Hugo Reis
Azevedo, Vânia Nakauth
Feitosa, Rosimar Neris Martins
Monteiro, Jacqueline Cortinhas
Silva, Andrea Nazaré Monteiro Rangel da
Ribeiro, Andre Luis Ribeiro
Oliveira-Filho, Aldemir Branco de
Vallinoto, Antonio Carlos Rosario
Machado, Luiz Fernando Almeida
xmlui.dri2xhtml.METS-1.0.item-abstract
Introduction - Human pegivirus 1 (HPgV-1) is a single-stranded, positive-sense RNA virus belonging to the Flaviviridae family with limited cause-effect evidence of the causation of human diseases. However, studies have shown a potential beneficial impact of HPgV-1 coinfection in HIV disease progression. Human T lymphotropic virus-1 (HTLV-1) is a retrovirus known for causing diseases, especially in muscle and white blood cells, in approximately 5% of patients. Thus, this study aimed to investigate the potential effects of an HPgV-1 infection in patients carrying HTLV-1 in the state of Pará in the North Region of Brazil. Methods - A group of HTLV-1 carriers was compared to healthy controls. Blood samples were collected, data from medical regards were collected, and a questionnaire was administered. HPgV-1 and HTLV-1 positivity was determined by quantitative polymerase chain reaction (qRT-PCR). The data were analyzed to correlate the effects of HPgV-1 coinfection in HTLV-1 carriers. Results - A total of 158 samples were included in the study: 74 HTLV-1-positive patients (46,8%) and 84 healthy controls (53,2%). The overall HPgV-1 positivity rate was 7.6% (12/158), resulting in a prevalence of 5.4% (4/74) and 9.5% (8/84) in HTLV-1 carriers and healthy controls, respectively. No significant differences were found when comparing any clinical or demographic data between groups. Conclusion - This study indicated that the prevalence of HPgV-1 infection is low in HTLV-1 carriers in Belém, Pará, and probably does not alter the clinical course of HTLV-1 infection, however, further studies are still needed.
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LIMA, Ana Beatriz Figueiredo de et al. Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Belém, Pará, North Region of Brazil. PLoS ONE , v. 15, n. 5, e0232783, 2020.xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Flaviviridae / isolamento & purificaçãoInfecções por Flaviviridae
Coinfecção
Vírus Linfotrópico T Tipo 1 Humano
Pegivírus Humano 1 (HPgV-1)