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dc.contributor.authorBatista-Gomes, Jéssica Almeida-
dc.contributor.authorMello Júnior, Fernando Augusto Rodrigues-
dc.contributor.authorOliveira, Edivaldo Herculano Corrêa de-
dc.contributor.authorSouza, Michel Platini Caldas de-
dc.contributor.authorWanderley, Alayde Vieira-
dc.contributor.authorPantoja, Laudreisa da Costa-
dc.contributor.authorSantos, Ney Pereira Carneiro dos-
dc.contributor.authorKhayat, Bruna Cláudia Meireles-
dc.contributor.authorKhayat, André Salim-
dc.date.accessioned2020-07-15T17:11:49Z-
dc.date.available2020-07-15T17:11:49Z-
dc.date.issued2020-
dc.identifier.citationBATISTA-GOMES, Jéssica Almeida et al. Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis. Molecular Cytogenetics, v. 13, n. 25, p. 1-8, 2020.pt_BR
dc.identifier.issn1755-8166-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/4116-
dc.description.abstractCopy number variations (CNVs) analysis may reveal molecular biomarkers and provide information on the pathogenesis of acute lymphoblastic leukemia (ALL). We investigated the gene copy number in childhood ALL by microarray and select three new recurrent CNVs to evaluate by real-time PCR assay: DMBT1, KIAA0125 and PRDM16 were selected due to high frequency of CNVs in ALL samples and based on their potential biological functions in carcinogenesis described in the literature. DBMT1 deletion was associated with patients with chromosomal translocations and is a potential tumor suppressor; KIAA0125 and PRDM16 may act as an oncogene despite having a paradoxical behavior in carcinogenesis. This study reinforces that microarrays/aCGH is it is a powerful tool for detection of genomic aberrations, which may be used in the risk stratificationpt_BR
dc.description.sponsorshipNational Counsel of Technological and Scientific Development (CNPq), grant n° 460185/2014–4 and Amazon Foundation for Research Support (FAPESPA), grant n° PPSUS/2013.pt_BR
dc.language.isoengpt_BR
dc.publisherBMCpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleIdentifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysispt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryLeucemia / patologiapt_BR
dc.subject.decsPrimaryLeucemia-Linfoma Linfoblástico de Células Precursoras / diagnósticopt_BR
dc.subject.decsPrimaryBiomarcadorespt_BR
dc.subject.decsPrimaryAnálise Citogenéticapt_BR
dc.subject.decsPrimaryDoenças Hematológicaspt_BR
dc.subject.decsPrimaryVariações do Número de Cópias de DNA / genéticapt_BR
dc.subject.decsPrimaryAberrações Cromossômicaspt_BR
dc.creator.affilliationFederal University of Pará. Oncology Research Center. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Oncology Research Center. Belém, PA, Brazil.pt-BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationOctávio Lobo Children’s Cancer Hospital. Belém, PA, Brazil.pt_BR
dc.creator.affilliationOctávio Lobo Children’s Cancer Hospital. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Oncology Research Center. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Oncology Research Center. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Oncology Research Center. Belém, PA, Brazil.pt_BR
dc.identifier.doi10.1186/s13039-020-00491-5-


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