Clinical and immunological features of human Leishmania (L.) infantum-Infection, novel insights Honduras, Central America
Chaves, Luis Fernando
Flores, Gabriela Venicia Araújo
Pacheco, Carmen Maria Sandoval
Matta, Vania Lúcia Ribeiro da
Corbett, Carlos Eduardo Pereira
Silveira, Fernando Tobias
Laurenti, Marcia Dalastra
Leishmania (Leishmania) infantum is the etiological agent of both American visceral leishmaniasis (AVL) and non-ulcerated cutaneous leishmaniasis (NUCL) in Honduras. Although AVL is the most severe clinical form of infection, recent studies have shown that human immune response to parasite infection can result in a clinical-immunological spectrum. The overall prevalence rate of infection and clinical-immunological profiles of the L. (L.) infantum infection in Amapala municipality, South Honduras was determined. We examined 576 individuals with diagnosis based on combined ELISA (IgG/IgM) and DTH assays. We also used genus-specific kDNA PCR and Hsp70 PCR-RFLP for NUCL cases. Clinical evaluation found 82% asymptomatic and 18% symptomatic individuals. All symptomatic cases (n = 104) showing NUCL were positive for parasites. We identified L. (L.) infantum species in 100% of the skin lesion scrapings and in 90% of the blood samples from NUCL cases studied. A total of 320 asymptomatic individuals were exposed (ELISA+ and/or DTH+), providing an overall L. (L.) infantum prevalence of 73.6%. Clinical, parasitological, and immunological evaluations suggest seven infection profiles, three asymptomatic and four symptomatic. This represents the first report on clinical and immunological features of human L. (L.) infantum-infection in Amapala municipality, Honduras.
xmlui.dri2xhtml.METS-1.0.item-citationSOSA-OCHOA, Wilfredo et al. Clinical and immunological features of human Leishmania (L.) infantum-Infection, novel insights Honduras, Central America. Pathogens, v. 9, n. 7, p. 1-15, 2020.
xmlui.dri2xhtml.METS-1.0.item-decsPrimaryLeishmaniose Visceral / parasitologia
Leishmania infantum / parasitologia
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