• Portal do Governo Brasileiro
  • Atualize sua Barra de Governo
Logo
    • English
    • español
    • português (Brasil)
    • English
    • español
    • português (Brasil)
  • xmlui.dri2xhtml.structural.login
xmlui.ArtifactBrowser.ItemViewer.trail 
  •   xmlui.general.dspace_home
  • SEÇÃO DE MEIO AMBIENTE
  • SAMAM - Artigos Científicos
  • xmlui.ArtifactBrowser.ItemViewer.trail
  •   xmlui.general.dspace_home
  • SEÇÃO DE MEIO AMBIENTE
  • SAMAM - Artigos Científicos
  • xmlui.ArtifactBrowser.ItemViewer.trail
JavaScript is disabled for your browser. Some features of this site may not work without it.

Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?

Thumbnail
xmlui.dri2xhtml.METS-1.0.item-date
2020
xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?.pdf (2.037xmlui.dri2xhtml.METS-1.0.size-megabytes)
xmlui.mirage2.itemSummaryView.MetaData
xmlui.ArtifactBrowser.ItemViewer.show_full
xmlui.dri2xhtml.METS-1.0.item-uri
http://patua.iec.gov.br//handle/iec/4170
xmlui.dri2xhtml.METS-1.0.item-author
Almeida, Deise Cibele N. de
Souza, Michel Platini Caldas de
Amorim, Carolina Koury Nassar
Maués, Jersey Heitor da Silva
Sagica, Fernanda do Espirito Santo
Moreira-Nunes, Caroline Aquino
Oliveria, Edivaldo Herculano Corrêa de
xmlui.dri2xhtml.METS-1.0.item-abstract
Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microarray-based analysis in two groups of patients (<45 and ≥45 years old), in order to verify the occurrence of specific copy number alterations (CNAs) that could be associated to different patient behaviors associated with age. Patients and Methods: In order to search and compare genomic alterations that may be related to age, we evaluated the occurrence of CNAs in the genome of 24 PTC samples, divided in two groups (<45 and ≥45 years old). Results: We identified only one region showing a statistically significant difference between the groups (p=0.00357): a deletion of approximately 537 kps in 1p35.3., which was more frequent in patients aged 45 years or older. This is the region where, among others, the gene SESN2 is located, which is activated under oxidative stress and plays an antioxidant role, in addition to protecting the genetic material from damage generated by reactive oxygen species (ROS). Conclusion: This is the first time that a CNA involving the deletion of the SESN2 gene is associated with papillary thyroid carcinomas, particularly in patients aged 45 years and older, indicating that this deletion would lead to a more malignant and prominent tumoral behavior associated to a worst prognosis.
xmlui.dri2xhtml.METS-1.0.item-citation
ALMEIDA, Deise Cibele N. de et al. Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?. Cancer Genomics and Proteomics, v. 17, n. 5, p. 643-648, Sept./Oct. 2020.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Neoplasias / diagnóstico
Neoplasias da Glândula Tireoide / diagnóstico
Câncer Papilífero da Tireoide
Estresse Oxidativo / genética
Idoso / fisiologia
Envelhecimento
xmlui.dri2xhtml.METS-1.0.item-rights
Acesso Aberto
xmlui.mirage2.itemSummaryView.Collections
  • CIT - Artigos Científicos
  • SAMAM - Artigos Científicos

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
Suporte ao site - Wesin Alves
 

 

xmlui.ArtifactBrowser.Navigation.head_browse

xmlui.ArtifactBrowser.Navigation.head_all_of_dspacexmlui.ArtifactBrowser.Navigation.communities_and_collectionsxmlui.ArtifactBrowser.Navigation.browse_dateissuedxmlui.ArtifactBrowser.Navigation.browse_authorxmlui.ArtifactBrowser.Navigation.browse_titlexmlui.ArtifactBrowser.Navigation.browse_subjectxmlui.ArtifactBrowser.Navigation.head_this_collectionxmlui.ArtifactBrowser.Navigation.browse_dateissuedxmlui.ArtifactBrowser.Navigation.browse_authorxmlui.ArtifactBrowser.Navigation.browse_titlexmlui.ArtifactBrowser.Navigation.browse_subject

xmlui.EPerson.Navigation.my_account

xmlui.EPerson.Navigation.loginxmlui.EPerson.Navigation.register

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
Suporte ao site - Wesin Alves