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dc.contributor.authorFalcão, Luiz Fábio Magno-
dc.contributor.authorPontes, Lucieny da Silva-
dc.contributor.authorSilva, Bruno Giovanni Afonso da-
dc.contributor.authorFranco, Karen Margarete Vieira da Silva-
dc.contributor.authorCosta, Luiz Adriano Araujo da-
dc.contributor.authorRocha, Rodrigo Santiago Barbosa-
dc.contributor.authorQuaresma, Juarez Antônio Simões-
dc.date.accessioned2020-10-13T13:22:21Z-
dc.date.available2020-10-13T13:22:21Z-
dc.date.issued2020-
dc.identifier.citationFALÇÃO, Luiz Fábio Magno et al. The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy. Reviews in Medical Virology, v. 31, n. 2, e2167, Mar. 2021.pt_BR
dc.identifier.issn1052-9276-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/4179pt_BR
dc.description.abstractCovid-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may present with polymorphic symptomatology and subclinical, neurological, gastrointestinal, dermatological, renal and severe acute respiratory manifestations. The diffuse alveolar damage caused by the disease presents with fibrin deposition, oedema, lymphocytic inflammatory infiltrate, destruction of epithelial cells, hyaline membrane formation and occasional angiogenesis formation of microthrombi. A common radiological finding is bilateral ground glass opacity, present even in mild cases. Severe cases occur mainly among the elderly and individuals with underlying comorbidities. Here, we provide an overview of the pathophysiology of the disease associated with SARS-CoV-2 infection, interaction of the virus with the immune system, and subsequent dysfunctional immune response, essential for progression of Covid-19. We also discuss the role of the nervous system as a possible aggravating agent of the respiratory condition and propose a protocol for airway management based on the pathophysiological and immunological characteristics of the disease. Finally, we highlight the implications of such approaches for future therapeutic intervention.pt_BR
dc.description.sponsorshipAmazon Foundationpt_BR
dc.language.isoengpt_BR
dc.publisherWileypt_BR
dc.rightsAcesso Embargadopt_BR
dc.titleThe complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapypt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimarySíndrome Respiratória Aguda Grave / imunologiapt_BR
dc.subject.decsPrimaryVírus da SARS / isolamento & purificaçãopt_BR
dc.subject.decsPrimaryCoronavirus / patogenicidadept_BR
dc.subject.decsPrimaryInfecções por Coronaviruspt_BR
dc.subject.decsPrimarySistema Nervosopt_BR
dc.subject.decsPrimaryLesão Pulmonar / patologiapt_BR
dc.subject.decsPrimaryManuseio das Vias Aéreaspt_BR
dc.creator.affilliationState University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationState University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationState University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Center for Tropical Medicine. Belém, PA, Brazil.pt_BR
dc.creator.affilliationState University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationState University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationState University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.identifier.doi10.1002/rmv.2167-


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