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dc.contributor.authorSousa, Jorge Rodrigues de-
dc.contributor.authorAzevedo, Raimunda do Socorro da Silva-
dc.contributor.authorQuaresma, Juarez Antônio Simões-
dc.contributor.authorVasconcelos, Pedro Fernando da Costa-
dc.date.accessioned2020-10-13T14:01:39Z-
dc.date.available2020-10-13T14:01:39Z-
dc.date.issued2020-
dc.identifier.citationSOUSA, Jorge Rodrigues de et al. The innate immune response in Zika virus infection. Reviews in Medical Virology, v. 31, n. 2, e2166, p. xx, Mar. 2021.pt_BR
dc.identifier.issn1052-9276-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/4180pt_BR
dc.description.abstractZika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive‐sense, single‐stranded RNA virus, which encodes a single polyprotein that is cleaved into 10 individual proteins. In 2015, the Zika‐epidemic in Brazil was marked mainly by the exponential growth of microcephaly cases and other congenital defects. With regard to host–pathogen relationships, understanding the role of the immune response in the pathogenesis ZIKV infection is challenging. The innate immune response is the first‐line immunological defence, in which pathogen‐associated molecular patterns are recognized by pattern‐recognition receptors that trigger macrophages, dendritic cells, natural killer cells and endothelial cells to produce several mediators, which modulate viral replication and immune evasion. In this review, we have summarized current knowledge on the innate immune response against ZIKV.pt_BR
dc.description.sponsorshipCAPES ; National Council for Scientific and Technological Development (CNPq) 303999/2016-0; 439971/2016-0; 440405/2016-5pt_BR
dc.language.isoengpt_BR
dc.publisherWileypt_BR
dc.rightsAcesso Embargadopt_BR
dc.titleThe innate immune response in Zika virus infectionpt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryZika virus / patogenicidadept_BR
dc.subject.decsPrimaryInfecção por Zika virus / imunologiapt_BR
dc.subject.decsPrimaryCitocinaspt_BR
dc.subject.decsPrimaryInterações Hospedeiro-Patógeno / imunologiapt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade do Estado do Pará. Belém, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade do Estado do Pará. Belém, PA, Brazil / Universidade Federal do Pará. Núcleo de Medicina Tropical. Belém, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade do Estado do Pará. Belém, PA, Brazil.pt_BR
dc.identifier.doi10.1002/rmv.2166-


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