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dc.contributor.authorCapobianco, Marcela Petrolini-
dc.contributor.authorCassiano, Gustavo Capatti-
dc.contributor.authorStorti-Melo, Luciane Moreno-
dc.contributor.authorPimenta, Tamirys Simão-
dc.contributor.authorRodrigues, Ana Paula Drummond-
dc.contributor.authorArruda, José Eduardo Gomes-
dc.contributor.authorPinto, Marcia Ribeiro-
dc.contributor.authorBaptista, Andrea Regina de Souza-
dc.contributor.authorPratt-Riccio, Lilian Rose-
dc.contributor.authorBonini-Domingos, Cláudia Regina-
dc.contributor.authorOliveira-Ferreira, Joseli de-
dc.contributor.authorMachado, Ricardo Luiz Dantas-
dc.date.accessioned2020-11-16T18:14:20Z-
dc.date.available2020-11-16T18:14:20Z-
dc.date.issued2020-
dc.identifier.citationCAPOBIANCO, Marcela Petrolini et al. Polymorphism in the IL-1β promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 114, n. 11, p. 858-865, Nov. 2020.pt_BR
dc.identifier.issn1878-3503-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/4201pt_BR
dc.description.abstractBACKGROUND: It is well established that infection by Plasmodium vivax is a result of host-parasite interactions. In the present study, association with the IL1/IL2 cytokine profiles, anticircumsporozoite protein antibody levels and parasitic loads was evaluated in individuals naturally infected with P. vivax in an endemic area of the Brazilian Amazon. METHODS: Molecular diagnosis of P. vivax and variants was performed using the PCR-RFLP method and IL1B -511C>T, IL2 -330T>G and IL2+114T>G polymorphisms were identified using PCR-RFLP and allele-specific PCR. IL-1β and IL-2 cytokine levels were detected by flow cytometry and circumsporozoite protein (CSP) antibodies were measured by ELISA. RESULTS: Three variants of P. vivax CSP were identified and VK247 was found to be the most frequent. However, the prevalence and magnitude of IgG antibodies were higher for the VK210 variant. Furthermore, the antibody response to the CSP variants was not associated with the presence of the variant in the infection. Significant differences were observed between the single nucleotide polymorphism (SNP) -511T>C in the IL1B gene and levels of antibodies to the VK247 and P. vivax-like variants, but there were no associations between SNPs in IL1 and IL2 genes and their plasma products. CONCLUSIONS: Individuals with the rs16944 CC genotype in the IL1β gene have higher antibody levels to the CSP of P. vivax of VK247 and P. vivax-like variants.pt_BR
dc.description.sponsorshipConselho Nacional para o Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil (CAPES – DS and PDSE) – Finance Code 001pt_BR
dc.language.isoengpt_BR
dc.publisherOxford University Presspt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePolymorphism in the IL-1β promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivaxpt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryPlasmodium vivax / parasitologiapt_BR
dc.subject.decsPrimaryPolimorfismo Genéticopt_BR
dc.subject.decsPrimaryCitocinaspt_BR
dc.subject.decsPrimaryProteína Circunsporozoítapt_BR
dc.subject.decsPrimaryAnticorpospt_BR
dc.subject.decsPrimaryInterleucina-1beta / genéticapt_BR
dc.subject.decsPrimaryGoianésia do Pará (PA)pt_BR
dc.creator.affilliationSão Paulo State University. Graduate Program in Biosciences. São José do Rio Preto, SP, Brazil.pt_BR
dc.creator.affilliationLisboa University. Tropical Medicine and Hygiene Institut. Global Health and Tropical Medicine. Lisboa, Portugal.pt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Biology. Aracajú, SE, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Imunogenética da Malária Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Ananindeua, PA, Brasil / Universidade Federal do Pará. Belém, PA, Brasil.pt_BR
dc.creator.affilliationFluminense Federal University. Center of Microorganisms Investigation. Niterói, RJ, Brazil.pt_BR
dc.creator.affilliationFluminense Federal University. Center of Microorganisms Investigation. Niterói, RJ, Brazil.pt_BR
dc.creator.affilliationFluminense Federal University. Center of Microorganisms Investigation. Niterói, RJ, Brazil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Oswaldo Cruz Institute. Laboratory of Malaria Research. Rio de Janeiro, RJ, Brazil.pt_BR
dc.creator.affilliationSão Paulo State University. Graduate Program in Biosciences. São José do Rio Preto, SP, Brazil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Oswaldo Cruz Institute. Laboratory of Immunoparasitology. Rio de Janeiro, RJ, Brazil.pt_BR
dc.creator.affilliationSão Paulo State University. Graduate Program in Biosciences. São José do Rio Preto, SP, Brazil / Fluminense Federal University. Center of Microorganisms Investigation. Niterói, RJ, Brazil.pt_BR
dc.identifier.doi10.1093/trstmh/traa055-


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