First report of canine infection by leishmania (Viannia) guyanensis in the brazilian amazon

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2020xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
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http://patua.iec.gov.br//handle/iec/4203xmlui.dri2xhtml.METS-1.0.item-author
Santos, Francisco J. A
Nascimento, Luciana de Cássia Silva do
Silva, Wellington Bandeira da
Oliveira, Luciana P
Santos, Walter Souza
Aguiar, Délia Cristina Figueira
Santos, Lourdes Maria Garcez dos
xmlui.dri2xhtml.METS-1.0.item-abstract
Abstract: The American cutaneous (CL) and visceral leishmaniasis (VL) are zooanthroponoses
transmitted by sand flies. Brazil records thousands of human leishmaniasis cases annually. Dogs are
reservoirs of Leishmania infantum, which causes VL, but their role in the transmission cycle of CL is
debatable. Wild mammals are considered reservoirs of the aetiological agents of CL (Leishmania spp.).
Objective: To describe the aetiology of leishmaniasis in dogs in an endemic area for CL and VL in
the Amazon, Brazil. Methods: Clinical evaluation and blood collection of 40 dogs from the villages
Ubim (20) and Socorro (20), city of Tomé-Açu, state of Pará, were carried out. The DNA extracted
from the blood was used for PCR with Leishmania-specific primers targeting the hsp70-234 gene
sequence. Products were sequenced (ABI3500XL), and the sequences were aligned, edited (BioEdit),
and analyzed (Blastn). Results: Of the 34 amplified samples, 21 were sequenced, namely Leishmania
infantum (12), L. guyanensis (5), L. braziliensis (3), and Leishmania sp. (01). Conclusion: Given the
diversity of circulating pathogens, elucidation of the role of the dog in the Leishmania spp. cycle in
Amazonian villages is imperative to the surveillance of CL in the region. We present the first report
in Brazil, confirmed by sequencing, of canine infection by L. guyanensis, a species highly resistant to
treatment in humans, with the drug of first choice (Glucantime®)
xmlui.dri2xhtml.METS-1.0.item-citation
SANTOS, Francisco J. A. et al. First report of canine infection by leishmania (Viannia) guyanensis in the brazilian amazon. International Journal of Environmental Research and Public Health, v. 17, n. 22, p. 1-9, Nov. 2020.xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Leishmania guyanensis / parasitologiaLeishmaniose / etiologia
Reservatórios de Doenças / veterinária
Cães / parasitologia
Tomé-Açu (PA)