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dc.contributor.authorSousa Júnior, Ivanildo Pedro de-
dc.contributor.authorOliveira, Maria de Lourdes Aguiar-
dc.contributor.authorBurlandy, Fernanda M-
dc.contributor.authorMachado, Raiana Scerni-
dc.contributor.authorOliveira, Silas S-
dc.contributor.authorTavares, Fernando N-
dc.contributor.authorGomes Neto, Francisco-
dc.contributor.authorCosta, Eliane V. da-
dc.contributor.authorSilva, Edson E. da-
dc.date.accessioned2020-12-15T17:33:44Z-
dc.date.available2020-12-15T17:33:44Z-
dc.date.issued2020-
dc.identifier.citationSOUSA JR., Ivanildo Pedro de et al. Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brasil: a historical series (2005-2017). Emerging Microbes & Infections, v. 9, p. 2536-2546, Dec. 2020.pt_BR
dc.identifier.issn2222-1751-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/4208-
dc.description.abstractDue to the advanced stage of polio eradication, the possible role of non-polio enteroviruses (NPEVs) associated to acute flaccid paralysis (AFP) cases has been highlighted. In this study, we described epidemiological aspects of NPEVs infections associated to AFP and explore the viral genetic diversity, information still scarce in Brazil. From 2005 to 2017, 6707 stool samples were collected in the scope of the Brazilian Poliomyelitis Surveillance Program. NPEVs were isolated in 359 samples (5.3%) and 341 (94.9%) were genotyped. About 46 different NPEV types were identified with the following detection pattern EV-B > EV-A > EV-C. The major EV-types were CVA2, CV4, EV-A71, CVB3, CVB5, E6, E7, E11, CVA13 and EV-C99, which corresponds to 51.6% of the total. Uncommon types, such as CVA12, EV-90 and CVA11, were also identified. Different E6 genogroups were observed, prevailing the GenIII, despite periods of co-circulation, and replacement of genogroups along time. CVA2 sequences were classified as genotype C and data suggested its dispersion in South-American countries. CVA13 viruses belonged to cluster B and Venezuelan viruses composed a new putative cluster. This study provides extensive information on enterovirus diversity associated with AFP, reinforcing the need of tailoring current surveillance strategies to timely monitor emergence/re-emergence of NPEVs.pt_BR
dc.language.isoengpt_BR
dc.publisherTaylor & Francispt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMolecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005–2017)pt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryEnteroviruspt_BR
dc.subject.decsPrimaryPoliomielite / patologiapt_BR
dc.subject.decsPrimaryEpidemiologia Molecularpt_BR
dc.subject.decsPrimaryPoliomielite / virologiapt_BR
dc.subject.decsPrimaryVigilânciapt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Referência Regional em Enteroviroses. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. Rio de Janeiro, RJ, Brasil.pt_BR
dc.identifier.doi10.1080/22221751.2020.1850181-


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