First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil
Santos, Anderson Lineu Siqueira dos
Rodrigues, Yan Corrêa
Melo, Marcos Vinícios Hino de
Santos, Pabllo Antonny Silva dos
Oliveira, Tatyellen Natasha da Costa
Sardinha, Daniele Melo
Lima, Luana Nepomuceno Gondim Costa
Brasiliense, Danielle Murici
Lima, Karla Valéria Batista
Abstract: Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state of Pará, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by K. pneumoniae 72 h after hospital admission. K. pneumoniae isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR K. pneumoniae isolates was observed, including two colistin-resistant isolates and seven isolates harboring blaKPC-1 gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by K. pneumoniae in the state of Pará, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of K. pneumoniae in the region.
xmlui.dri2xhtml.METS-1.0.item-citationSANTOS, Anderson Lineu Siqueira dos et al. First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil. Infectious Disease Reports, v. 12, n. 3, p. 110-120, Dec. 2020.
xmlui.dri2xhtml.METS-1.0.item-decsPrimaryNeoplasias / patologia
Klebsiella pneumoniae / patogenicidade
Infecções por Klebsiella / microbiologia
Resistência a Múltiplos Medicamentos