Layered double hydroxide–indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases

xmlui.dri2xhtml.METS-1.0.item-date
2020xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
xmlui.mirage2.itemSummaryView.MetaData
xmlui.ArtifactBrowser.ItemViewer.show_fullxmlui.dri2xhtml.METS-1.0.item-uri
http://patua.iec.gov.br//handle/iec/4224xmlui.dri2xhtml.METS-1.0.item-author
Meneses, Carla Carolina Ferreira
Sousa, Paulo Robson Monteiro
Pinto, Laine Celestino
Coelho, Gerson Maciel
Silva, Tamires Ferreira da
Ferreira, Luan Oliveira
Gustavo, Kayo Silva
Martins Filho, Arnaldo Jorge
Faial, Kelson do Carmo Freitas
Yamada, Elizabeth Sumi
Lameira, Jerônimo
Jouin, Jenny
Thomas, Philippe
Masson, Oliver
Lopes, Dielly Catrina Favacho
Alves, Cláudio Nahum
xmlui.dri2xhtml.METS-1.0.item-abstract
Indomethacin (INDO) demonstrates therapeutic efficacy in the treatment of neuroinflammatory diseases. Despite its importance as a drug, INDO causes gastrointestinal problems and adverse reactions in the central nervous system (CNS). In this study, we prepared nanoparticles of layered double hydroxide (LDH) loaded with INDO. The structure of the nanohybrid (LDH-INDO) was synthesized via a coprecipitation method, and the nanohybrid was characterized using X-ray powder diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis–differential scanning colorimetry (TGA–DSC), field-emission scanning electron microscopy (FE-SEM), and ultraviolet (UV)–vis spectroscopy. Moreover, the drug release profiles of the nanohybrid were investigated using kinetic models. INDO was incorporated within the LDH interlayer space with 50% intercalation. The release of INDO anions from LDH-INDO after 10 h was 90% at pH 4.8 ± 0.02 and 51% at pH 7.4 ± 0.02. The results show that the release profiles follow a pseudo-second-order model. In addition, lipopolysaccharide (LPS)-induced sickness behavior in animals and treatment with INDO and LDH-INDO suggest recovery of the variables (weight and food intake) used in this study. LDH-INDO did not alter hepatic and renal biomarkers. Moreover, LPS increased the number of Iba1+ cells (microgliosis) and caused morphological alterations in these cells in the hippocampus and somatosensory cortex. However, the LPS effect was attenuated after treatment with INDO, both free and LDH-intercalated, in both regions of the brain.
xmlui.dri2xhtml.METS-1.0.item-citation
MENESES, Carla Carolina Ferreira et al. Layered double hydroxide–indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases. Journal of Drug Delivery Science and Technology, v. xx, 102190, p. xx, Oct. 2020xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Sistema Nervoso CentralIndometacina / administração & dosagem