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dc.contributor.authorMeneses, Carla Carolina Ferreira-
dc.contributor.authorSousa, Paulo Robson Monteiro-
dc.contributor.authorPinto, Laine Celestino-
dc.contributor.authorCoelho, Gerson Maciel-
dc.contributor.authorSilva, Tamires Ferreira da-
dc.contributor.authorFerreira, Luan Oliveira-
dc.contributor.authorGustavo, Kayo Silva-
dc.contributor.authorMartins-Filho, Arnaldo Jorge-
dc.contributor.authorFaial, Kelson do Carmo Freitas-
dc.contributor.authorYamada, Elizabeth Sumi-
dc.contributor.authorLameira, Jerônimo-
dc.contributor.authorJouin, Jenny-
dc.contributor.authorThomas, Philippe-
dc.contributor.authorMasson, Oliver-
dc.contributor.authorLopes, Dielly Catrina Favacho-
dc.contributor.authorAlves, Cláudio Nahum-
dc.date.accessioned2021-01-26T14:12:52Z-
dc.date.available2021-01-26T14:12:52Z-
dc.date.issued2020-
dc.identifier.citationMENESES, Carla Carolina Ferreira et al. Layered double hydroxide–indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases. Journal of Drug Delivery Science and Technology, v. xx, 102190, p. xx, Oct. 2020pt_BR
dc.identifier.issn1773-2247-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/4224-
dc.description.abstractIndomethacin (INDO) demonstrates therapeutic efficacy in the treatment of neuroinflammatory diseases. Despite its importance as a drug, INDO causes gastrointestinal problems and adverse reactions in the central nervous system (CNS). In this study, we prepared nanoparticles of layered double hydroxide (LDH) loaded with INDO. The structure of the nanohybrid (LDH-INDO) was synthesized via a coprecipitation method, and the nanohybrid was characterized using X-ray powder diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis–differential scanning colorimetry (TGA–DSC), field-emission scanning electron microscopy (FE-SEM), and ultraviolet (UV)–vis spectroscopy. Moreover, the drug release profiles of the nanohybrid were investigated using kinetic models. INDO was incorporated within the LDH interlayer space with 50% intercalation. The release of INDO anions from LDH-INDO after 10 h was 90% at pH 4.8 ± 0.02 and 51% at pH 7.4 ± 0.02. The results show that the release profiles follow a pseudo-second-order model. In addition, lipopolysaccharide (LPS)-induced sickness behavior in animals and treatment with INDO and LDH-INDO suggest recovery of the variables (weight and food intake) used in this study. LDH-INDO did not alter hepatic and renal biomarkers. Moreover, LPS increased the number of Iba1+ cells (microgliosis) and caused morphological alterations in these cells in the hippocampus and somatosensory cortex. However, the LPS effect was attenuated after treatment with INDO, both free and LDH-intercalated, in both regions of the brain.pt_BR
dc.language.isoengpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Embargadopt_BR
dc.titleLayered double hydroxide–indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseasespt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimarySistema Nervoso Centralpt_BR
dc.subject.decsPrimaryIndometacina / administração & dosagempt_BR
dc.creator.affilliationFederal University of Pará. Institute of Exact and Natural Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Exact and Natural Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Exact and Natural Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationUniversité de Limoges. Centre Européen de la Céramique. Laboratoire IRCER. Limoges, Francept_BR
dc.creator.affilliationUniversité de Limoges. Centre Européen de la Céramique. Laboratoire IRCER. Limoges, Francept_BR
dc.creator.affilliationUniversité de Limoges. Centre Européen de la Céramique. Laboratoire IRCER. Limoges, Francept_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Exact and Natural Sciences. Belém, PA, Brazil.pt_BR
dc.identifier.doi10.1016/j.jddst.2020.102190-


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