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Imaging microstructural damage and alveolar bone loss in rats systemically exposed to methylmercury: first experimental evidence

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2021
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Imaging microstructural damage and alveolar bone loss in rats systemically exposed to methylmercury: first experimental evidence.pdf (538.1xmlui.dri2xhtml.METS-1.0.size-kilobytes)
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http://patua.iec.gov.br//handle/iec/4233
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Lopes, Géssica de Oliveira
Aragão, Walessa Alana Bragança
Bittencourt, Leonardo Oliveira
Puty, Bruna
Lopes, Armando Pereira
Santos, Sávio Monteiro dos
Monteiro, Marta Chagas
Oliveira, Edivaldo Herculano Corrêa de
Silva, Márcia Cristina Freitas da
Lima, Rafael Rodrigues
xmlui.dri2xhtml.METS-1.0.item-abstract
The alveolar bone is an important mineralized structure of the periodontal support apparatus, and information about the methylmercury (MeHg) effects on the structural integrity is scarce. Therefore, this study aimed to investigate whether systemic, chronic, and low-dose exposure to MeHg can change the alveolar bone microstructure of rats. Adult Wistar rats (n = 30) were exposed to 0.04 mg/kg/day of MeHg or vehicle through intragastric gavage. The animals were euthanized after 60 days, and blood samples were collected for trolox equivalent antioxidant capacity (TEAC), glutathione (GSH), lipid peroxidation (LPO), and comet assays. The mandible of each animal was collected and separated into hemimandibles that were used to determine the total Hg level in the bone and to analyze microstructural damage and alveolar bone loss in terms of trabecular number (Tb.N), trabecular thickness (Tb.Th), bone volume fraction (BV/TV), and exposed root area of the second molars. MeHg exposure triggered oxidative stress in blood represented by lower levels of GSH and TEAC and the increase in LPO and DNA damage of the blood cells. High total Hg levels were found in the alveolar bone, and the microstructural analyses showed a reduction in Tb.N, Tb.Th, and BV/TV, which resulted in an increase in the exposed root area and a decrease in bone height. Long-term MeHg exposure promotes a systemic redox imbalance associated with microstructural changes and alveolar bone loss and may indicate a potential risk indicator for periodontal diseases.
xmlui.dri2xhtml.METS-1.0.item-citation
LOPES, Géssica de Oliveira et al. Imaging microstructural damage and alveolar bone loss in rats systemically exposed to methylmercury: first experimental evidence. Biological Trace Element Research, v. xx, n. xx, p. xx, Jan. 2021.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Mercúrio / análise
Ratos Wistar / anatomia & histologia
Perda do Osso Alveolar
Periodonto
Microtomografia por Raio-X / métodos
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  • SAMAM - Artigos Científicos

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br