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dc.contributor.authorSalazar, Marielba de los Ángeles Rodríguez-
dc.contributor.authorUrbina, Glides Rafael Olivo-
dc.contributor.authorCunha, Vânia Maria Borges-
dc.contributor.authorBezerra, Fernanda Wariss Figueiredo-
dc.contributor.authorDias, Michelle Nerissa Coelho-
dc.contributor.authorSantos, Ijair Rogério-
dc.contributor.authorTeixeira, Bruno José Brito-
dc.contributor.authorCosta, Wanessa Almeida-
dc.contributor.authorLeal, Walace Gomes-
dc.contributor.authorSouza, Jesus Nazareno Silva e-
dc.contributor.authorSilva, Silvia Helena Marques-
dc.contributor.authorCarvalho Junior, Raul Nunes-
dc.date.accessioned2021-02-03T17:10:47Z-
dc.date.available2021-02-03T17:10:47Z-
dc.date.issued2021-
dc.identifier.citationSALAZAR, Marielba de los Ángeles Rodríguez et al. Cytotoxic effect of cipó-pucá (Cissus sicyoides L.) supercritical extract on human red blood cells and as anti-inflammatory in spinal cord injury in adult rats. The Journal of Supercritical Fluids, v. 169, n. xx, p. xx, Feb. 2021.pt_BR
dc.identifier.issn0896-8446-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/4238-
dc.description.abstractCissus sicyoides L. is a plant that has great anti-inflammatory activity, due to the presence of phenolic compounds. The objective of this work was to identify such substances by HPLC and to evaluate the cytotoxic effect on human red blood cells, of the C. sicyoides extract obtained by supercritical extraction, using CO2 and EtOH as co-solvent, in comparison to the extract obtained by conventional extraction (Soxhlet), as well as, to evaluate its anti-inflammatory effect on spinal cord injury (SCI) in adult rats. In HPLC analysis, the UV/Visible spectral data revealed compounds with absorption bands in wavelengths characteristic of glycosylated flavonoids. The supercritical extract did not show cytotoxic effect, as there was no rupture of red blood cell membranes. The in vivo test demonstrated reduction in cell concentration in the lesion surrounding area in treated animals, suggesting an anti-inflammatory effect of the supercritical extract on the SCI model.pt_BR
dc.language.isoengpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Embargadopt_BR
dc.titleCytotoxic effect of cipó-pucá (Cissus sicyoides L.) supercritical extract on human red blood cells and as anti-inflammatory in spinal cord injury in adult ratspt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryPlantas Medicinais / químicapt_BR
dc.subject.decsPrimaryCissus / análisept_BR
dc.subject.decsPrimaryCissus / químicapt_BR
dc.subject.decsPrimaryCompostos Fenólicos / análisept_BR
dc.subject.decsPrimaryExtratos Vegetais / uso terapêuticopt_BR
dc.subject.decsPrimaryCromatografia Líquida de Alta Pressão / métodospt_BR
dc.creator.affilliationFederal University of Pará. Program of Post-Graduation in Food Science and Technology. Extraction Laboratory. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Program of Post-Graduation in Food Science and Technology. Extraction Laboratory. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Program of Post-Graduation in Food Science and Technology. Extraction Laboratory. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Program of Post-Graduation in Food Science and Technology. Extraction Laboratory. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Laboratory of Neuroprotection and Experimental Neurorregeneration. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Laboratory of Neuroprotection and Experimental Neurorregeneration. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Center for Valorization of Amazonian Bioactive Compounds. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Program of Post-Graduation in Food Science and Technology. Extraction Laboratory. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Laboratory of Neuroprotection and Experimental Neurorregeneration. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Center for Valorization of Amazonian Bioactive Compounds. Belém, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationFederal University of Pará. Program of Post-Graduation in Food Science and Technology. Extraction Laboratory. Belém, PA, Brazil.pt_BR
dc.identifier.doi10.1016/j.supflu.2020.105105-


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