Prenatal disorders and congenital Zika syndrome in squirrel monkeys

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2021xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
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http://patua.iec.gov.br//handle/iec/4248xmlui.dri2xhtml.METS-1.0.item-author
Imbeloni, Aline Amaral
Alcantara, Bianca Nascimento de
Coutinho, Leandro Nassar
Scalercio, Sarah Raphaella Rocha de Azevedo
Carneiro, Liliane Almeida
Oliveira, Karol Guimarães
Martins Filho, Arnaldo Jorge
Durans, Darlene de Brito Simith
Silva, Wellington Bandeira da
Nunes, Bruno Tardelli Diniz
Casseb, Livia Medeiros Neves
Chiang, Jannifer Oliveira
Carvalho, Carlos Alberto Marques de
Machado, Mariana Borges
Quaresma, Juarez Antônio Simões
Medeiros, Daniele Barbosa de Almeida
Vasconcelos, Pedro Fernando da Costa
xmlui.dri2xhtml.METS-1.0.item-abstract
During the Zika virus (ZIKV) outbreak in Brazil (2015–2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this study, we evaluated the prenatal conditions of pregnant female squirrel monkeys (Saimiri collinsi) infected during different gestational thirds (GTs) and assessed all clinical aspects, diagnostic imaging, viremia and the immune response. In our study, 75% of the infected animals in the 1st GT group had significant clinical manifestations, such as miscarriage and prolonged viremia associated with a late immune response. Consequently, their neonates showed fetal neuropathology, such as cerebral hemorrhage, lissencephaly or malformations of the brain grooves, ventriculomegaly, and craniofacial malformations. Thus, our study demonstrated the relevance of pregnant squirrel monkeys as a model for the study of ZIKV infection in neonates due to the broad clinical manifestations presented, including the typical congenital Zika syndrome manifestations described in humans.
xmlui.dri2xhtml.METS-1.0.item-citation
IMBELONI, Aline Amaral et al. Prenatal disorders and congenital Zika syndrome in squirrel monkeys. Scientific Reports, v. 11, n. 1, p. 1-11, Dec. 2021.xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Primatas / anatomia & histologiaSaimiri / anatomia & histologia
Zika virus / patogenicidade
Infecção por Zika virus / complicações
Infecção por Zika virus / veterinária
Anormalidades Congênitas / veterinária