Microglial plasticity contributes to recovery of bone marrow mononuclear cells during experimental stroke

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2021xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
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http://patua.iec.gov.br//handle/iec/4254xmlui.dri2xhtml.METS-1.0.item-author
Franco, Edna Cristina Santos
Cardoso, Marcelo Marques
Souza, Celice Cordeiro de
Silva, Michelle Castro da
Santos, Carolina Ramos dos
Leal, Walace Gomes
xmlui.dri2xhtml.METS-1.0.item-abstract
Brain stroke is an acute neural disorder characterized by obstruction (ischemic) or
rupture (hemorrhagic) of blood vessels causing neural damage and subsequent functional
impairment. Its pathophysiology is complex and involves a multitude of pathological
events including energetic collapse, excitotoxicity, oxidative stress, metabolic
acidosis, cell death and neuroinflammation. Despite its clinical importance, there
is no effective pharmacological therapies available to diminish secondary damage
avowing functional deficits. Considering the failure of pharmacological approaches
for stroke, cell therapy came as promising alternative. Different cell types have been
investigated in different experimental models with promising results. An important
issue regarding the transplantation of stem cells into the damaged CNS tissue is how
the pathological environment influences the transplanted cells. It has been established
that an exacerbated inflammation in the pathological environment is detrimental to
the survival of the transplanted stem cells. This prompted us to develop an experimental
strategy to improve the therapeutic actions of bone marrow mononuclear cells
(BMMCs) transplanted into the acute phase of brain stroke by modulating microglial
activation with minocycline. In this chapter, we first review the basic pathophysiology
of ischemic stroke with emphasis on the role of microglia to the pathological outcome.
We then review the experimental approach of modulating microglia activation in
order to enhance therapeutic actions of BMMCS for experimental stroke. We suggest
that such an approach may be applied as an adjuvant therapy to control excessive
neuroinflammation in the pathological environment allowing acute transplants and
improving therapeutic actions of different kind of stem cells.
xmlui.dri2xhtml.METS-1.0.item-citation
FRANCO. Edna Cristina S. et al. Microglial plasticity contributes to recovery of bone marrow mononuclear cells during experimental stroke. In: MACROPHAGES. InterchOpen. 2021. Disponível em: https://www.intechopen.com/online-first/microglial-plasticity-contributes-to-recovery-of-bone-marrow-mononuclear-cells-during-experimental-s. Acesso em 09 fev. 2021.xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Sistema Nervoso Central / lesõesAcidente Vascular Cerebral
Microglia
Células-Tronco / ultraestrutura
Terapia Baseada em Transplante de Células e Tecidos / métodos
Neuroproteção