Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil

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Resende, Paola Cristina
Delatorre, Edson
Graf, Tiago
Mir, Daiana
Motta, Fernando Couto
Appolinario, Luciana Reis
Paixão, Anna Carolina Dias da
Mendonça, Ana Carolina da Fonseca
Ogrzewalska, Maria
Caetano, Braulia
Wallau, Gabriel Luz
Docena, Cássio
Santos, Mirleide Cordeiro dos
Ferreira, Jessylene de Almeida
Sousa Júnior, Edivaldo Costa
Silva, Sandro Patroca da
Fernandes, Sandra Bianchini
Vianna, Lucas Alves
Souza, Larissa da Costa
Ferro, Jean F. G
Nardy, Vanessa B
Santos, Cliomar A
Riediger, Irina
Debur, Maria do Carmo
Croda, Júlio
Oliveira, Wanderson Kleber
Abreu, André
Bello, Gonzalo
Siqueira, Marilda M
xmlui.dri2xhtml.METS-1.0.item-abstract
A previous study demonstrates that most of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Brazilian strains fell in three local clades that were introduced from Europe around late February 2020. Here we investigated in more detail the origin of the major and most widely disseminated SARS-CoV-2 Brazilian lineage B.1.1.33. We recovered 190 whole viral genomes collected from 13 Brazilian states from February 29 to April 31, 2020 and combined them with other B.1.1 genomes collected globally. Our genomic survey confirms that lineage B.1.1.33 is responsible for a variable fraction of the community viral transmissions in Brazilian states, ranging from 2% of all SARS-CoV-2 genomes from Pernambuco to 80% of those from Rio de Janeiro. We detected a moderate prevalence (5-18%) of lineage B.1.1.33 in some South American countries and a very low prevalence (<1%) in North America, Europe, and Oceania. Our study reveals that lineage B.1.1.33 evolved from an ancestral clade, here designated B.1.1.33-like, that carries one of the two B.1.1.33 synapomorphic mutations. The B.1.1.33-like lineage may have been introduced from Europe or arose in Brazil in early February 2020 and a few weeks later gave origin to the lineage B.1.1.33. These SARS-CoV-2 lineages probably circulated during February 2020 and reached all Brazilian regions and multiple countries around the world by mid-March, before the implementation of air travel restrictions in Brazil. Our phylodynamic analysis also indicates that public health interventions were partially effective to control the expansion of lineage B.1.1.33 in Rio de Janeiro because its median effective reproductive number (R e ) was drastically reduced by about 66% during March 2020, but failed to bring it to below one. Continuous genomic surveillance of lineage B.1.1.33 might provide valuable information about epidemic dynamics and the effectiveness of public health interventions in some Brazilian states.
xmlui.dri2xhtml.METS-1.0.item-citation
RESENDE, Paola Cristina et al. Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil. Frontiers in Microbiology, v. 11, n. 615280, Feb. 2021.xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Vírus da SARS / patogenicidadeSíndrome Respiratória Aguda Grave / patologia
Infecções por Coronavirus
Mutação / genética
Epidemias
Linhagem