Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys

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2021xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
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http://patua.iec.gov.br//handle/iec/4271xmlui.dri2xhtml.METS-1.0.item-author
Alcantara, Bianca Nascimento de
Imbeloni, Aline Amaral
Durans, Darlene de Brito Simith
Araújo, Marialva Tereza Ferreira de
Cruz, Ermelinda do Rosário Moutinho da
Carvalho, Carlos Alberto Marques de
Mendonça, Maria Helena Rodrigues de
Sousa, Jorge Rodrigues de
Moraes, Adriana Freitas
Martins Filho, Arnaldo Jorge
Lima, Maria de Lourdes Gomes
Amador Neto, Orlando Pereira
Chiang, Jannifer Oliveira
Scalercio, Sarah Raphaella Rocha de Azevedo
Carneiro, Liliane Almeida
Quaresma, Juarez Antônio Simões
Vasconcelos, Pedro Fernando da Costa
Medeiros, Daniele Barbosa de Almeida
xmlui.dri2xhtml.METS-1.0.item-abstract
The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a neotropical primate (which mimics the stages of human pregnancy), as a model of Zika virus (ZIKV) infection. Seven pregnant female squirrel monkeys were experimentally infected at three different gestational stages, and we were able reproduce a broad range of clinical manifestations of ZIKV lesions observed in newborn humans. Histopathological and immunohistochemical analyses of early-infected newborns (2/4) revealed damage to various areas of the brain and ZIKV antigens in the cytoplasm of neurons and glial cells, indicative of CZS. The changes caused by ZIKV infection were intrauterine developmental delay, ventriculomegaly, simplified brain gyri, vascular impairment and neuroprogenitor cell dysfunction. Our data show that the ZIKV infection outcome in squirrel monkeys is similar to that in humans, indicating that this model can be used to help answer questions about the effect of ZIKV infection on neuroembryonic development and the morphological changes induced by CZS.
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ALCANTARA, Bianca Nascimento de et al. Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys. Scientific Reports, v. 11, n. 6099, 2021.xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Primatas / anatomia & histologiaSaimiri / anatomia & histologia
Primatas / lesões
Infecção por Zika virus / veterinária
Cérebro / lesões
Exame Neurológico / veterinária