Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection
Brito, Caio Vinicius Botelho
Rodrigues, Érika Dayane Leal
Martins, Fernanda Monik Silva
Tavares, Lavínia Dias
Lima, André Luis de Sousa Nogueira
Ferreira, Lucas Carvalho
Santana, Carlos Junior Lopes
Brito, João Augusto Gomes de Souza Monteiro de
Casseb, Lívia Medeiros Neves
Diniz Júnior, José Antônio Picanço
Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution of the disease. One of the drugs used is biopterin, which is an important cofactor for nitric oxide, important for preventing vasospasm. Thus, we describe the effect of biopterin on some inflammatory factors in a rabies virus infection developed in an animal model. The immunological mediators studied in animals infected with rabies virus submitted to doses of sapropterin were Anti-RABV, IL-6, IL-2, IL-17a, INF-gamma and Anti-iNOS. It is suggested that the medication in the context of a RABV infection already installed, had the effect of modulating the inflammatory mechanisms mainly linked to the permeability of the blood-brain barrier and the migration of cytotoxic cells.
xmlui.dri2xhtml.METS-1.0.item-citationBRITO, Caio Vinicius Botelho et al. Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection. Revista do Instituto de Medicina Tropical de Sao Paulo, v. 63, n. e28, p. 1-7, Apr. 2021.
xmlui.dri2xhtml.METS-1.0.item-decsPrimaryRaiva / patologia
Vírus da Raiva / patogenicidade
Sistema Nervoso Central / efeitos dos fármacos