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dc.contributor.authorVale, Tiago Gurgel do-
dc.contributor.authorLima, Daiana Correia-
dc.contributor.authorLima, Eliângela de-
dc.contributor.authorTorres, Laila Brito-
dc.contributor.authorCossa, Ana Carolina-
dc.contributor.authorCavalheiro, Esper Abrão-
dc.contributor.authorNaffah-Mazzacoratti, Maria da Graça-
dc.contributor.authorOliveira, Elaine Menezes de-
dc.contributor.authorAmado, Débora-
dc.contributor.authorSilva, Alexandre Valotta da-
dc.contributor.authorCabral, Francisco Romero-
dc.date.accessioned2016-01-26T11:27:48Z-
dc.date.issued2010-
dc.identifier.citationVALE, Tiago Gurgel do et al. Seizures during pregnancy modify the development of hippocampal interneurons of the offspring. Epilepsy & Behavior, v. 19, n. 1, p. 20-25, 2010.pt_BR
dc.identifier.issn1525-5050-
dc.identifier.urihttp://patua.iec.gov.br/handle/iec/443-
dc.description.abstractWe investigated the effect of epileptic seizures during pregnancy on hippocampal expression of calciumbindingproteins in the offspring. Female Wistar rats were submitted to the pilocarpine model and mated during the chronic period. Seizure frequency was monitored over the entire pregnancy. Pups were perfusedat postnatal days 6 and 13, and the brains processed for Nissl staining and immunohistochemistry for NeuN,calbindin, calretinin, and parvalbumin. Number of stained cells in the hippocampus was estimated throughstereological methods. Our results showed a decrease in epileptic seizure frequency during pregnancy. Nodifferences were observed in NeuN-positive, CR-positive cells, and Nissl-stained hippocampal neuronsbetween the groups. However, there was a significant decrease in calbindin-positive cells (P=0.005) and asignificant increase in parvalbumin-positive cells (P=0.02) in the experimental group when compared withthe control group. These results suggest that seizures during pregnancy affect the development of specifichippocampal interneurons of the offspring.pt_BR
dc.format.mimetypeapplication/pdf-
dc.language.isoengpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleSeizures during pregnancy modify the development of hippocampal interneurons of the offspringpt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryEpilepsiapt_BR
dc.subject.decsPrimaryRatospt_BR
dc.subject.decsPrimaryHipocampopt_BR
dc.creator.affilliationUniversidade Federal de São Paulo. Disciplina de Neurologia Experimental. São Paulo, SP, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal de São Paulo. Campus Baixada Santista. Departamento de Biociências. Mathias-Santos, SP, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal de São Paulo. Disciplina de Neurologia Experimental. São Paulo, SP, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal de São Paulo. Disciplina de Neurologia Experimental. São Paulo, SP, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Centro Nacional de Primatas. Belém, PA, Brasil / Universidade Federal de São Paulo. Disciplina de Neurologia Experimental. São Paulo, SP, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal de São Paulo. Disciplina de Neurologia Experimental. São Paulo, SP, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal de São Paulo. Disciplina de Neurologia Experimental. São Paulo, SP, Brasil.pt_BR
dc.creator.affilliationInstituto de Ensino e Pesquisa Hospital Albert Einstein. Instituto do Cérebro. São Paulo, SP, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal de São Paulo. Disciplina de Neurologia Experimental. São Paulo, SP, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal de São Paulo. Disciplina de Neurologia Experimental. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Campus Baixada Santista. Departamento de Biociências. Mathias-Santos, SP, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal de São Paulo. Disciplina de Neurologia Experimental. São Paulo, SP, Brasil.pt_BR
dc.identifier.doi10.1016/j.yebeh.2010.06.032-


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