Rapamycin even when combined with cyclosporine attenuates tumor growth but does not induce regression of established walker sarcomas
Silva, S. L
Silva, S. F. R
Farias, I. N
Mota, R. S
Carvalho, Reinaldo de Amorim
Moraes, M. O
Moraes, M. E
Campos, H. de Holanda
Purpose. To investigate the effect of rapamycin (Rapa) on growth or regression of Walker tumor used alone or in combination with CsA and MMF. Methods and results. Wistar rats received water (control) or Rapa or CsA 1 day before and daily after tumor inoculation. On day 10, tumor volume (TV) was smaller among Rapa (6.8 2.7 cm3 ) versus control (14.9 4.2 cm3 , P .001) or CsA (13.9 3.0 cm3 , P .0001) treatment groups. Tumor growth was greatly inhibited (TI) by Rapa (49.3%). Tumor weight (TW) was significantly (P .001) lower in Rapa (3.7 1.2 g) versus CsA (8.8 2.1 g) or control (7.3 2.0 g) animals. An additional set of rats received water or Rapa or CsA Rapa, or MMF Rapa 1 day before tumor inoculation. On day 10, TV and TW were lower among Rapa (3.8 1.5 cm3 ) and Rapa CsA (3.1 1.2 cm3 ) and Rapa MMF (4.6 2.7 cm3 ) groups compared with controls (10.9 3.8 cm3 , P .0001). TI was 52.1% in Rapa, 68.5% in Rapa CsA, and 63% in Rapa MMF. A further set of rats received either water or Rapa on the day 4 after tumor inoculation. On day 10, tumor growth and TW among the Rapa and control groups were similar. Conclusion. Rapamycin greatly inhibited tumor growth when used alone or with CsA or MMF, but did not produce an effect on a well-established Walker sarcoma.
xmlui.dri2xhtml.METS-1.0.item-citationSILVA, S. L. et al. Rapamycin even when combined with cyclosporine attenuates tumor growth but does not induce regression of established walker sarcomas. Transplantation Proceedings, v. 36, n. 4, p. 934-937, 2004.
xmlui.dri2xhtml.METS-1.0.item-decsPrimarySirolimo / uso terapêutico
Carcinoma 256 de Walker
Inoculação de Neoplasia
Carcinoma 256 de Walker / induzido quimicamente