An analysis of the influence of sex hormones on Balb/c mice infected with Plasmodium berghei
Lopes, Letícia Nobre
Santos, Felipe Augusto Folha
Oliveira, Louize Caroline Marques
Araujo, Marialva Tereza Ferreira
Sequeira, Carina Guilhon
Libonati, Rosana Maria Feio
Ventura, Ana Maria Revorêdo da Silva
Sex steroids can determine several responses in the clinical evolution of malaria. Seventy Balb-c mice were randomly distributed into 7 groups (10 mice per group): G1 to G6 corresponding to castrated females, castrated females that received estradiol cypionate, uncastrated females, castrated males, castrated males that received intramuscular testosterone decanoate and uncastrated males infected with Plasmodium berghei, and G7, the control group. The mice were evaluated with regard to survival, parasitemia, temperature, body weight, hemoglobin level (anemia) and splenic index. Castrated infected females had lower rates of survival. In the castrated male, the administration of testosterone had anegative influence on survival. There was a progressive increase in parasitemia without repercussions forsurvival. Castration had a significant influence on weight gain in females. Weight loss was observed in all mice, except those in groups G2 and G5, although this bore no direct relation to parasitemia. A significant and progressive decline in temperature and hemoglobin levels occurred in mice over the course of their infection, which differed from the G7 group. The weight of the spleen in relation to total body weight did not differ among the groups of infected mice, but was significantly higher than it was for the control group.
xmlui.dri2xhtml.METS-1.0.item-citationLOPES, Letícia Nobre et al. An analysis of the influence of sex hormones on Balb/c mice infected with Plasmodium berghei. Microbial Pathogenesis, v. 90, p. 7-12, 2015.
xmlui.dri2xhtml.METS-1.0.item-decsPrimaryHormônios Esteroides Gonadais
Plasmodium berghei / efeitos de drogas
Parasitemia / parasitologia
Camundongos Endogâmicos BALB C
Modelos Animais de Doenças
Taxa de Sobrevida