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dc.contributor.authorPóvoa, Marinete Marins-
dc.contributor.authorAdagu, I. S-
dc.contributor.authorOliveira, Sueli Guerreiro-
dc.contributor.authorMachado, Ricardo Luiz Dantas-
dc.contributor.authorMiles, M. A-
dc.contributor.authorWarhurst, D. C-
dc.date.accessioned2016-01-26T11:36:40Z-
dc.date.available2016-01-26T11:36:40Z-
dc.date.issued1998-
dc.identifier.citationPÓVOA, Marinete Marins et al. Pfmdr1 Asn1042 Asp and Asp 1246Tyr polymorphisms, thought to be associated with chloroquine resistance, are present in chloroquine-resistant and - sensitive Brazilian field isolates of Plasmodium falciparum. Experimental Parasitology, v. 88, n. 1, p. 64-68, 1998.pt_BR
dc.identifier.issn0014-4894-
dc.identifier.urihttp://patua.iec.gov.br/handle/iec/684-
dc.description.abstractParasite resistance to antimalarial drugs, particularly chloroquine, is the most disturbing problem of malaria chemotherapy. There is evidence that the codon 86Tyr polymorphism of the Pfmdr1 gene is associated with chloroquine resistance in West African Plasmodium falciparum. The association of this and four other coding alterations of the Pfmdr1 gene with chloroquine resistance has not been extensively investigated in South American isolates. In this study, we examined 51 Brazilian P. falciparum isolates for the presence or absence of Asn86Tyr, Asn1042Asp, and Asp1246Tyr polymorphisms. While these isolates were all sensitive in vitro to mefloquine, amodiaquine, and quinine, only 2 (4 percent) were chloroquine-sensitive. The findings reported here provide the first observations of this kind on a large number of field parasite samples from South America. We show that in vitro chloroquine-resistant and -sensitive strains carry the Asn1042Asp and Asp1246Tyr polymorphisms and provide support for earlier suggestions that Asn86Tyr may be rare or absent in South American P. falciparum.pt_BR
dc.format.mimetypeapplication/pdf-
dc.language.isoengpt_BR
dc.publisherAcademic Presspt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePfmdr1 Asn1042Asp and Asp1246Tyr polymorphisms, thought to be associated with chloroquine resistance, are present in chloroquine-resistant and - sensitive Brazilian field isolates of Plasmodium falciparum.pt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryPlasmodium falciparum / parasitologiapt_BR
dc.subject.decsPrimaryPlasmodium falciparum / isolamento & purificaçãopt_BR
dc.subject.decsPrimaryResistência a Medicamentospt_BR
dc.subject.decsPrimaryMalária / quimioterapiapt_BR
dc.subject.decsPrimaryAntimaláricos / efeitos adversospt_BR
dc.subject.decsPrimaryAntimaláricos / análisept_BR
dc.subject.decsPrimaryAntimaláricos / farmacocinéticapt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationLondon School of Hygiene and Tropical Medicine. Department of Medical Parasitology. London, UK.pt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationLondon School of Hygiene and Tropical Medicine. Department of Medical Parasitology. London, UK.pt_BR
dc.creator.affilliationLondon School of Hygiene and Tropical Medicine. Department of Medical Parasitology. London, UK.pt_BR


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