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dc.contributor.authorSilveira, Fernando Tobias-
dc.contributor.authorCarneiro, Liliane Almeida-
dc.contributor.authorRamos, Patrícia Karla Santos-
dc.contributor.authorChagas, Eugênia J-
dc.contributor.authorLima, Luciana V. R-
dc.contributor.authorCampos, Marliane Batista-
dc.contributor.authorLaurenti, Márcia D-
dc.contributor.authorGomes, Claudia Maria de Castro-
dc.contributor.authorCorbett, Carlos Eduardo Pereira-
dc.date.accessioned2016-01-26T11:37:00Z-
dc.date.available2016-01-26T11:37:00Z-
dc.date.issued2012-
dc.identifier.citationSILVEIRA, Fernando Tobias et al. A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs. Parasitology Research, v. 111, p. 1513-1522, 2012.pt_BR
dc.identifier.urihttp://patua.iec.gov.br/handle/iec/868-
dc.description.abstractThis was a cross-sectional study which analyzed the prevalence and the clinical and immunological spectrum of canine Leishmania (L.) infantum chagasi infection in a cohort of 320 mongrel dogs living in an endemic area of American visceral leishmaniasis in the Amazonian Brazil by using, mainly, the indirect fluorescence antibody test (IFAT-IgG) and the delayed-type hypersensitivity (DTH), and the parasite research by the popliteal lymph node aspiration. The IFAT and DTH reactivity recognized three different immune response profiles: (1) IFAT((+))/DTH((-)) (107 dogs), (2) IFAT((-))/DTH((+)) (18 dogs), and (3) IFAT((+))/DTH((+)) (13 dogs), providing an overall prevalence of infection of 43 per cent (138/320). Thus, the specific prevalence of IFAT( (+) )/DTH( (-) ) 33.4 per cent (107/320) was higher than those of IFAT( (-) )/DTH( (+) ) 5.6 per cent (18/320) and IFAT( (+) )/DTH( (+) ) 4.0 per cent (13/320). Moreover, the frequency of these profiles among 138 infected dogs showed that the IFAT( (+) )/DTH( (-) ) rate of 77.5 per cent (107/138) was also higher than those of 13.0 per cent (18/138) of IFAT( (-) )/DTH( (+) ) and 9.5 per cent (13/138) of IFAT( (+) )/DTH( (+) ) rates. The frequency of asymptomatic dogs (76 per cent-105) was higher than those of symptomatic (16.6 per cent-23) and oligosymptomatic ones (7.4 per cent-10). A total of 16 (11.6 per cent) L. (L.) i. chagasi isolates were obtained from infected dogs, all from the IFAT( (+) ) /DTH( (-) ) profile: 41 per cent (9/22) from symptomatic, 33.3 per cent (3/9) from oligosymptomatic, and 5.2 per cent (4/76) from asymptomatic dogs. These findings strongly suggested that despite the higher frequency of asymptomatic dogs (76 per cent-105), the majority (72.4 per cent-76) was characterized by the IFAT( (+) ) /DTH( (-) ) profile with a doubtful immunogenetic resistance against infection.pt_BR
dc.format.mimetypeapplication/pdf-
dc.language.isoengpt_BR
dc.publisherSpringer Internationalpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleA cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogspt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryLeishmania infantum / parasitologiapt_BR
dc.subject.decsPrimaryLeishmaniose Visceral / transmissãopt_BR
dc.subject.decsPrimaryEstudos Transversaispt_BR
dc.subject.decsPrimarySaúde Públicapt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Federal University of Pará. Tropical Medicine Institute. Belém, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationPublic Health Department. Health Care Secretary of Barcarena. Barcarena, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMedical School of São Paulo University. Pathology Department. São Paulo, SP, Brazil.pt_BR
dc.creator.affilliationMedical School of São Paulo University. Pathology Department. São Paulo, SP, Brazil.pt_BR
dc.creator.affilliationMedical School of São Paulo University. Pathology Department. São Paulo, SP, Brazilpt_BR
dc.identifier.doi10.1007/s00436-012-2989-4-


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